Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage.
Publication
, Journal Article
Saunders, KO; Ward-Caviness, C; Schutte, RJ; Freel, SA; Overman, RG; Thielman, NM; Cunningham, CK; Kepler, TB; Tomaras, GD
Published in: Cell Immunol
2011
CD8(+) T-lymphocytes can utilize noncytolytic mechanisms to suppress HIV-1 replication through the secretion of soluble factors. The secretion of MIP-1β, MIP-1α, IP-10, MIG, IL-1α, and interferon gamma correlated most strongly with soluble noncytolytic suppression (p<0.0001). Since the noncytolytic response is impaired by histone hyperacetylation, we examined the ability of histone hyperacetylation to alter the expression of immune-related genes. MIP-1α and IP-10 were also among the genes that were down-regulated by histone hyperacetylation. We define a multifactorial cytokine profile of CD8(+) T-lymphocytes capable of mediating noncytolytic suppression of CXCR4-tropic HIV-1 replication.
Duke Scholars
Published In
Cell Immunol
DOI
EISSN
1090-2163
Publication Date
2011
Volume
266
Issue
2
Start / End Page
154 / 164
Location
Netherlands
Related Subject Headings
- Virus Replication
- Valproic Acid
- Up-Regulation
- Interferon-gamma
- Immunology
- Humans
- Histones
- HIV-1
- HIV Infections
- Gene Expression
Citation
APA
Chicago
ICMJE
MLA
NLM
Saunders, K. O., Ward-Caviness, C., Schutte, R. J., Freel, S. A., Overman, R. G., Thielman, N. M., … Tomaras, G. D. (2011). Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage. Cell Immunol, 266(2), 154–164. https://doi.org/10.1016/j.cellimm.2010.09.011
Saunders, Kevin O., Cavin Ward-Caviness, Robert J. Schutte, Stephanie A. Freel, R Glenn Overman, Nathan M. Thielman, Coleen K. Cunningham, Thomas B. Kepler, and Georgia D. Tomaras. “Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage.” Cell Immunol 266, no. 2 (2011): 154–64. https://doi.org/10.1016/j.cellimm.2010.09.011.
Saunders KO, Ward-Caviness C, Schutte RJ, Freel SA, Overman RG, Thielman NM, et al. Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage. Cell Immunol. 2011;266(2):154–64.
Saunders, Kevin O., et al. “Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage.” Cell Immunol, vol. 266, no. 2, 2011, pp. 154–64. Pubmed, doi:10.1016/j.cellimm.2010.09.011.
Saunders KO, Ward-Caviness C, Schutte RJ, Freel SA, Overman RG, Thielman NM, Cunningham CK, Kepler TB, Tomaras GD. Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage. Cell Immunol. 2011;266(2):154–164.
Published In
Cell Immunol
DOI
EISSN
1090-2163
Publication Date
2011
Volume
266
Issue
2
Start / End Page
154 / 164
Location
Netherlands
Related Subject Headings
- Virus Replication
- Valproic Acid
- Up-Regulation
- Interferon-gamma
- Immunology
- Humans
- Histones
- HIV-1
- HIV Infections
- Gene Expression