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Cell invasion through basement membrane: the anchor cell breaches the barrier.

Publication ,  Journal Article
Hagedorn, EJ; Sherwood, DR
Published in: Current opinion in cell biology
October 2011

Cell invasion through basement membrane (BM) is a specialized cellular behavior critical to many normal developmental events, immune surveillance, and cancer metastasis. A highly dynamic process, cell invasion involves a complex interplay between cell-intrinsic elements that promote the invasive phenotype, and cell-cell and cell-BM interactions that regulate the timing and targeting of BM transmigration. The intricate nature of these interactions has made it challenging to study cell invasion in vivo and model in vitro. Anchor cell invasion in Caenorhabditis elegans is emerging as an important experimental paradigm for comprehensive analysis of BM invasion, revealing the gene networks that specify invasive behavior and the interactions that occur at the cell-BM interface.

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Published In

Current opinion in cell biology

DOI

EISSN

1879-0410

ISSN

0955-0674

Publication Date

October 2011

Volume

23

Issue

5

Start / End Page

589 / 596

Related Subject Headings

  • Vertebrates
  • Neoplasms
  • Humans
  • Developmental Biology
  • Cell Movement
  • Cell Membrane
  • Caenorhabditis elegans
  • Basement Membrane
  • Animals
  • 3101 Biochemistry and cell biology
 

Citation

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Hagedorn, E. J., & Sherwood, D. R. (2011). Cell invasion through basement membrane: the anchor cell breaches the barrier. Current Opinion in Cell Biology, 23(5), 589–596. https://doi.org/10.1016/j.ceb.2011.05.002
Hagedorn, Elliott J., and David R. Sherwood. “Cell invasion through basement membrane: the anchor cell breaches the barrier.Current Opinion in Cell Biology 23, no. 5 (October 2011): 589–96. https://doi.org/10.1016/j.ceb.2011.05.002.
Hagedorn EJ, Sherwood DR. Cell invasion through basement membrane: the anchor cell breaches the barrier. Current opinion in cell biology. 2011 Oct;23(5):589–96.
Hagedorn, Elliott J., and David R. Sherwood. “Cell invasion through basement membrane: the anchor cell breaches the barrier.Current Opinion in Cell Biology, vol. 23, no. 5, Oct. 2011, pp. 589–96. Epmc, doi:10.1016/j.ceb.2011.05.002.
Hagedorn EJ, Sherwood DR. Cell invasion through basement membrane: the anchor cell breaches the barrier. Current opinion in cell biology. 2011 Oct;23(5):589–596.
Journal cover image

Published In

Current opinion in cell biology

DOI

EISSN

1879-0410

ISSN

0955-0674

Publication Date

October 2011

Volume

23

Issue

5

Start / End Page

589 / 596

Related Subject Headings

  • Vertebrates
  • Neoplasms
  • Humans
  • Developmental Biology
  • Cell Movement
  • Cell Membrane
  • Caenorhabditis elegans
  • Basement Membrane
  • Animals
  • 3101 Biochemistry and cell biology