Cardiovascular and neuromuscular effects of dimethyl sulfoxide in anesthetized rabbits.
Publication
, Journal Article
Domer, FR; Chihal, DM; Charles, HC
Published in: J Pharm Sci
February 1977
In rabbits anesthetized with pentobarbital, the carotid arterial blood pressure and bilateral contractions of the gastrocnemius muscles due to electrical stimulation of the sciatic nerves were recorded. Intravenous administration of up to 1 ml of dimethyl sulfoxide/kg caused profound hypotension and eventually failure of neuromuscular transmission. Caution must be used in considering dimethyl sulfoxide as a solvent for drug administration.
Duke Scholars
Published In
J Pharm Sci
DOI
ISSN
0022-3549
Publication Date
February 1977
Volume
66
Issue
2
Start / End Page
269 / 270
Location
United States
Related Subject Headings
- Respiration
- Rabbits
- Pharmacology & Pharmacy
- Neuromuscular Junction
- Myocardial Contraction
- Muscle Contraction
- Hemodynamics
- Dimethyl Sulfoxide
- Blood Pressure
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Domer, F. R., Chihal, D. M., & Charles, H. C. (1977). Cardiovascular and neuromuscular effects of dimethyl sulfoxide in anesthetized rabbits. J Pharm Sci, 66(2), 269–270. https://doi.org/10.1002/jps.2600660234
Domer, F. R., D. M. Chihal, and H. C. Charles. “Cardiovascular and neuromuscular effects of dimethyl sulfoxide in anesthetized rabbits.” J Pharm Sci 66, no. 2 (February 1977): 269–70. https://doi.org/10.1002/jps.2600660234.
Domer FR, Chihal DM, Charles HC. Cardiovascular and neuromuscular effects of dimethyl sulfoxide in anesthetized rabbits. J Pharm Sci. 1977 Feb;66(2):269–70.
Domer, F. R., et al. “Cardiovascular and neuromuscular effects of dimethyl sulfoxide in anesthetized rabbits.” J Pharm Sci, vol. 66, no. 2, Feb. 1977, pp. 269–70. Pubmed, doi:10.1002/jps.2600660234.
Domer FR, Chihal DM, Charles HC. Cardiovascular and neuromuscular effects of dimethyl sulfoxide in anesthetized rabbits. J Pharm Sci. 1977 Feb;66(2):269–270.
Published In
J Pharm Sci
DOI
ISSN
0022-3549
Publication Date
February 1977
Volume
66
Issue
2
Start / End Page
269 / 270
Location
United States
Related Subject Headings
- Respiration
- Rabbits
- Pharmacology & Pharmacy
- Neuromuscular Junction
- Myocardial Contraction
- Muscle Contraction
- Hemodynamics
- Dimethyl Sulfoxide
- Blood Pressure
- Animals