Skip to main content

Quantification of macular ischaemia in sickle cell retinopathy.

Publication ,  Journal Article
Lee, CM; Charles, HC; Smith, RT; Peachey, NS; Cunha-Vaz, JG; Goldberg, MF
Published in: Br J Ophthalmol
July 1987

Macular ischaemia has a central role in the pathophysiology and prognosis of retinal macular disease. We attempted to quantitate two of its major components as follows: vascular nonperfusion, by measuring the foveal avascular zone (FAZ), using fluorescein angiography; and functional damage, using automated perimetry of the central 30 degrees. Sickle cell disease was chosen for study because it was considered a prototype for a purely ischaemic retinopathy without an exudative component. We found that the FAZ measurement was reproducible and that the patients with maculopathy had statistically larger FAZs than the normal controls (p = 0.016, Wilcoxon rank sum test). In addition, scotomas measured by visual field perimetry were significantly larger in the sickle cell patients with maculopathy than in those without maculopathy. Our results showed that angiography and perimetry of the central 30 degrees were more sensitive tests for the detection of ischaemic macular disease than visual acuity and that macular ischaemia could be quantified by their use.

Duke Scholars

Published In

Br J Ophthalmol

DOI

ISSN

0007-1161

Publication Date

July 1987

Volume

71

Issue

7

Start / End Page

540 / 545

Location

England

Related Subject Headings

  • Visual Fields
  • Visual Field Tests
  • Sickle Cell Trait
  • Retinal Diseases
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macula Lutea
  • Ischemia
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lee, C. M., Charles, H. C., Smith, R. T., Peachey, N. S., Cunha-Vaz, J. G., & Goldberg, M. F. (1987). Quantification of macular ischaemia in sickle cell retinopathy. Br J Ophthalmol, 71(7), 540–545. https://doi.org/10.1136/bjo.71.7.540
Lee, C. M., H. C. Charles, R. T. Smith, N. S. Peachey, J. G. Cunha-Vaz, and M. F. Goldberg. “Quantification of macular ischaemia in sickle cell retinopathy.Br J Ophthalmol 71, no. 7 (July 1987): 540–45. https://doi.org/10.1136/bjo.71.7.540.
Lee CM, Charles HC, Smith RT, Peachey NS, Cunha-Vaz JG, Goldberg MF. Quantification of macular ischaemia in sickle cell retinopathy. Br J Ophthalmol. 1987 Jul;71(7):540–5.
Lee, C. M., et al. “Quantification of macular ischaemia in sickle cell retinopathy.Br J Ophthalmol, vol. 71, no. 7, July 1987, pp. 540–45. Pubmed, doi:10.1136/bjo.71.7.540.
Lee CM, Charles HC, Smith RT, Peachey NS, Cunha-Vaz JG, Goldberg MF. Quantification of macular ischaemia in sickle cell retinopathy. Br J Ophthalmol. 1987 Jul;71(7):540–545.

Published In

Br J Ophthalmol

DOI

ISSN

0007-1161

Publication Date

July 1987

Volume

71

Issue

7

Start / End Page

540 / 545

Location

England

Related Subject Headings

  • Visual Fields
  • Visual Field Tests
  • Sickle Cell Trait
  • Retinal Diseases
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macula Lutea
  • Ischemia
  • Humans