Skip to main content
Journal cover image

Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy.

Publication ,  Journal Article
Charles, HC; Lazeyras, F; Krishnan, KR; Boyko, OB; Payne, M; Moore, D
Published in: Prog Neuropsychopharmacol Biol Psychiatry
November 1994

1. Seven subjects with depression and matched controls were studied using proton spectroscopy to test the hypothesis that choline will be elevated in depression. 2. The proton spectroscopy was repeated after recovery from depression. 3. The study confirmed a state dependent increase in choline in the brain. 4. This change may be used as an in vivo marker of change in depression.

Duke Scholars

Published In

Prog Neuropsychopharmacol Biol Psychiatry

DOI

ISSN

0278-5846

Publication Date

November 1994

Volume

18

Issue

7

Start / End Page

1121 / 1127

Location

England

Related Subject Headings

  • Psychiatry
  • Psychiatric Status Rating Scales
  • Middle Aged
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Depressive Disorder
  • Choline
  • Brain Chemistry
  • Aspartic Acid
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Charles, H. C., Lazeyras, F., Krishnan, K. R., Boyko, O. B., Payne, M., & Moore, D. (1994). Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy. Prog Neuropsychopharmacol Biol Psychiatry, 18(7), 1121–1127. https://doi.org/10.1016/0278-5846(94)90115-5
Charles, H. C., F. Lazeyras, K. R. Krishnan, O. B. Boyko, M. Payne, and D. Moore. “Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy.Prog Neuropsychopharmacol Biol Psychiatry 18, no. 7 (November 1994): 1121–27. https://doi.org/10.1016/0278-5846(94)90115-5.
Charles HC, Lazeyras F, Krishnan KR, Boyko OB, Payne M, Moore D. Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Nov;18(7):1121–7.
Charles, H. C., et al. “Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy.Prog Neuropsychopharmacol Biol Psychiatry, vol. 18, no. 7, Nov. 1994, pp. 1121–27. Pubmed, doi:10.1016/0278-5846(94)90115-5.
Charles HC, Lazeyras F, Krishnan KR, Boyko OB, Payne M, Moore D. Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Nov;18(7):1121–1127.
Journal cover image

Published In

Prog Neuropsychopharmacol Biol Psychiatry

DOI

ISSN

0278-5846

Publication Date

November 1994

Volume

18

Issue

7

Start / End Page

1121 / 1127

Location

England

Related Subject Headings

  • Psychiatry
  • Psychiatric Status Rating Scales
  • Middle Aged
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Depressive Disorder
  • Choline
  • Brain Chemistry
  • Aspartic Acid