Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy.
Publication
, Journal Article
Charles, HC; Lazeyras, F; Krishnan, KR; Boyko, OB; Payne, M; Moore, D
Published in: Prog Neuropsychopharmacol Biol Psychiatry
November 1994
1. Seven subjects with depression and matched controls were studied using proton spectroscopy to test the hypothesis that choline will be elevated in depression. 2. The proton spectroscopy was repeated after recovery from depression. 3. The study confirmed a state dependent increase in choline in the brain. 4. This change may be used as an in vivo marker of change in depression.
Duke Scholars
Published In
Prog Neuropsychopharmacol Biol Psychiatry
DOI
ISSN
0278-5846
Publication Date
November 1994
Volume
18
Issue
7
Start / End Page
1121 / 1127
Location
England
Related Subject Headings
- Psychiatry
- Psychiatric Status Rating Scales
- Middle Aged
- Magnetic Resonance Imaging
- Image Processing, Computer-Assisted
- Humans
- Depressive Disorder
- Choline
- Brain Chemistry
- Aspartic Acid
Citation
APA
Chicago
ICMJE
MLA
NLM
Charles, H. C., Lazeyras, F., Krishnan, K. R., Boyko, O. B., Payne, M., & Moore, D. (1994). Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy. Prog Neuropsychopharmacol Biol Psychiatry, 18(7), 1121–1127. https://doi.org/10.1016/0278-5846(94)90115-5
Charles, H. C., F. Lazeyras, K. R. Krishnan, O. B. Boyko, M. Payne, and D. Moore. “Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy.” Prog Neuropsychopharmacol Biol Psychiatry 18, no. 7 (November 1994): 1121–27. https://doi.org/10.1016/0278-5846(94)90115-5.
Charles HC, Lazeyras F, Krishnan KR, Boyko OB, Payne M, Moore D. Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Nov;18(7):1121–7.
Charles, H. C., et al. “Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy.” Prog Neuropsychopharmacol Biol Psychiatry, vol. 18, no. 7, Nov. 1994, pp. 1121–27. Pubmed, doi:10.1016/0278-5846(94)90115-5.
Charles HC, Lazeyras F, Krishnan KR, Boyko OB, Payne M, Moore D. Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Nov;18(7):1121–1127.
Published In
Prog Neuropsychopharmacol Biol Psychiatry
DOI
ISSN
0278-5846
Publication Date
November 1994
Volume
18
Issue
7
Start / End Page
1121 / 1127
Location
England
Related Subject Headings
- Psychiatry
- Psychiatric Status Rating Scales
- Middle Aged
- Magnetic Resonance Imaging
- Image Processing, Computer-Assisted
- Humans
- Depressive Disorder
- Choline
- Brain Chemistry
- Aspartic Acid