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Relation of level of B-type natriuretic peptide with outcomes in patients with infective endocarditis.

Publication ,  Journal Article
Shiue, AB; Stancoven, AB; Purcell, JB; Pinkston, K; Wang, A; Khera, A; de Lemos, JA; Peterson, GE
Published in: Am J Cardiol
October 1, 2010

Elevated B-type natriuretic peptide (BNP) is a marker of poor outcomes in heart failure, acute coronary syndromes, and sepsis. Elevated cardiac troponin I (cTnI) is associated with adverse outcomes in infective endocarditis. It was hypothesized that elevated BNP would be associated with increased rates of morbidity and mortality in patients with infective endocarditis, particularly when combined with elevated cTnI. Consecutively enrolled patients in the International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) were evaluated at a single center. The association between elevated BNP and a composite outcome of death, intracardiac abscess, and central nervous system event and the individual components of the composite was determined. Similar analyses were performed in patients who had BNP and cTnI measured. Of 103 patients, 45 had BNP measured for clinical indications. The median BNP level was higher in patients with the composite outcome (1,498 vs 433 pg/ml, p = 0.03) and in those who died (2,150 vs 628 pg/ml, p = 0.04). Elevated BNP was significantly associated with the composite outcome (p <0.01) and intracardiac abscess (p = 0.02). Patients with elevation of BNP and cTnI had a significantly higher probability of the composite outcome (69%) than patients with either BNP or cTnI elevated (29%) or neither BNP nor troponin elevated (0%) (p for trend <0.01). In conclusion, these data demonstrate a significant association between elevated BNP alone and in combination with cTnI for serious outcomes in infective endocarditis and warrant prospective evaluation.

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Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

October 1, 2010

Volume

106

Issue

7

Start / End Page

1011 / 1015

Location

United States

Related Subject Headings

  • Troponin I
  • Risk Factors
  • Predictive Value of Tests
  • Natriuretic Peptide, Brain
  • Middle Aged
  • Male
  • Humans
  • Female
  • Endocarditis
  • Cardiovascular System & Hematology
 

Citation

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Shiue, A. B., Stancoven, A. B., Purcell, J. B., Pinkston, K., Wang, A., Khera, A., … Peterson, G. E. (2010). Relation of level of B-type natriuretic peptide with outcomes in patients with infective endocarditis. Am J Cardiol, 106(7), 1011–1015. https://doi.org/10.1016/j.amjcard.2010.05.034
Shiue, Angela B., Amy B. Stancoven, Jonathan B. Purcell, Kristi Pinkston, Andrew Wang, Amit Khera, James A. de Lemos, and Gail E. Peterson. “Relation of level of B-type natriuretic peptide with outcomes in patients with infective endocarditis.Am J Cardiol 106, no. 7 (October 1, 2010): 1011–15. https://doi.org/10.1016/j.amjcard.2010.05.034.
Shiue AB, Stancoven AB, Purcell JB, Pinkston K, Wang A, Khera A, et al. Relation of level of B-type natriuretic peptide with outcomes in patients with infective endocarditis. Am J Cardiol. 2010 Oct 1;106(7):1011–5.
Shiue, Angela B., et al. “Relation of level of B-type natriuretic peptide with outcomes in patients with infective endocarditis.Am J Cardiol, vol. 106, no. 7, Oct. 2010, pp. 1011–15. Pubmed, doi:10.1016/j.amjcard.2010.05.034.
Shiue AB, Stancoven AB, Purcell JB, Pinkston K, Wang A, Khera A, de Lemos JA, Peterson GE. Relation of level of B-type natriuretic peptide with outcomes in patients with infective endocarditis. Am J Cardiol. 2010 Oct 1;106(7):1011–1015.
Journal cover image

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

October 1, 2010

Volume

106

Issue

7

Start / End Page

1011 / 1015

Location

United States

Related Subject Headings

  • Troponin I
  • Risk Factors
  • Predictive Value of Tests
  • Natriuretic Peptide, Brain
  • Middle Aged
  • Male
  • Humans
  • Female
  • Endocarditis
  • Cardiovascular System & Hematology