Skip to main content
Journal cover image

Automated spectral analysis III: application to in vivo proton MR spectroscopy and spectroscopic imaging.

Publication ,  Journal Article
Soher, BJ; Young, K; Govindaraju, V; Maudsley, AA
Published in: Magn Reson Med
December 1998

An automated method for analysis of in vivo proton magnetic resonance (MR) spectra and reconstruction of metabolite distributions from MR spectroscopic imaging (MRSI) data is described. A parametric spectral model using acquisition specific, a priori information is combined with a wavelet-based, nonparametric characterization of baseline signals. For image reconstruction, the initial fit estimates were additionally modified according to a priori spatial constraints. The automated fitting procedure was applied to four different examples of MRS data obtained at 1.5 T and 4.1 T. For analysis of major metabolites at medium TE values, the method was shown to perform reliably even in the presence of large baseline signals and relatively poor signal-to-noise ratios typical of in vivo proton MRSI. Identification of additional metabolites was also demonstrated for short TE data. Automated formation of metabolite images will greatly facilitate and expand the clinical applications of MR spectroscopic imaging.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

December 1998

Volume

40

Issue

6

Start / End Page

822 / 831

Location

United States

Related Subject Headings

  • Software Design
  • Protons
  • Nuclear Medicine & Medical Imaging
  • Models, Statistical
  • Magnetic Resonance Spectroscopy
  • Humans
  • Evaluation Studies as Topic
  • Databases as Topic
  • Creatine
  • Computer Simulation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Soher, B. J., Young, K., Govindaraju, V., & Maudsley, A. A. (1998). Automated spectral analysis III: application to in vivo proton MR spectroscopy and spectroscopic imaging. Magn Reson Med, 40(6), 822–831. https://doi.org/10.1002/mrm.1910400607
Soher, B. J., K. Young, V. Govindaraju, and A. A. Maudsley. “Automated spectral analysis III: application to in vivo proton MR spectroscopy and spectroscopic imaging.Magn Reson Med 40, no. 6 (December 1998): 822–31. https://doi.org/10.1002/mrm.1910400607.
Soher BJ, Young K, Govindaraju V, Maudsley AA. Automated spectral analysis III: application to in vivo proton MR spectroscopy and spectroscopic imaging. Magn Reson Med. 1998 Dec;40(6):822–31.
Soher, B. J., et al. “Automated spectral analysis III: application to in vivo proton MR spectroscopy and spectroscopic imaging.Magn Reson Med, vol. 40, no. 6, Dec. 1998, pp. 822–31. Pubmed, doi:10.1002/mrm.1910400607.
Soher BJ, Young K, Govindaraju V, Maudsley AA. Automated spectral analysis III: application to in vivo proton MR spectroscopy and spectroscopic imaging. Magn Reson Med. 1998 Dec;40(6):822–831.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

December 1998

Volume

40

Issue

6

Start / End Page

822 / 831

Location

United States

Related Subject Headings

  • Software Design
  • Protons
  • Nuclear Medicine & Medical Imaging
  • Models, Statistical
  • Magnetic Resonance Spectroscopy
  • Humans
  • Evaluation Studies as Topic
  • Databases as Topic
  • Creatine
  • Computer Simulation