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Confidence images for MR spectroscopic imaging.

Publication ,  Journal Article
Young, K; Khetselius, D; Soher, BJ; Maudsley, AA
Published in: Magn Reson Med
October 2000

Automated spectral analysis and estimation of signal amplitudes from magnetic resonance data generally constitutes a difficult nonlinear optimization problem. Obtaining a measure of the degree of confidence that one has in the estimated parameters is as important as the estimates themselves. This is particularly important if clinical diagnoses are to be based on estimated metabolite levels, as in applications of MR Spectroscopic Imaging for human studies. In this report, a standard method of obtaining confidence intervals for nonlinear estimation is applied to simulated data and short-TE clinical proton spectroscopic imaging data sets of human brain. So-called "confidence images" are generated to serve as visual indicators of how much trust should be placed in interpretation of spatial variations seen in images derived from fitted metabolite parameter estimates. This method is introduced in a Bayesian framework to enable comparison with similar techniques using Cramer-Rao bounds and the residuals of fitted results.

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Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

October 2000

Volume

44

Issue

4

Start / End Page

537 / 545

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Brain
  • Bayes Theorem
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering
 

Citation

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ICMJE
MLA
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Young, K., Khetselius, D., Soher, B. J., & Maudsley, A. A. (2000). Confidence images for MR spectroscopic imaging. Magn Reson Med, 44(4), 537–545. https://doi.org/10.1002/1522-2594(200010)44:4<537::aid-mrm7>3.0.co;2-8
Young, K., D. Khetselius, B. J. Soher, and A. A. Maudsley. “Confidence images for MR spectroscopic imaging.Magn Reson Med 44, no. 4 (October 2000): 537–45. https://doi.org/10.1002/1522-2594(200010)44:4<537::aid-mrm7>3.0.co;2-8.
Young K, Khetselius D, Soher BJ, Maudsley AA. Confidence images for MR spectroscopic imaging. Magn Reson Med. 2000 Oct;44(4):537–45.
Young, K., et al. “Confidence images for MR spectroscopic imaging.Magn Reson Med, vol. 44, no. 4, Oct. 2000, pp. 537–45. Pubmed, doi:10.1002/1522-2594(200010)44:4<537::aid-mrm7>3.0.co;2-8.
Young K, Khetselius D, Soher BJ, Maudsley AA. Confidence images for MR spectroscopic imaging. Magn Reson Med. 2000 Oct;44(4):537–545.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

October 2000

Volume

44

Issue

4

Start / End Page

537 / 545

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Brain
  • Bayes Theorem
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering