Assessment of 3D proton MR echo-planar spectroscopic imaging using automated spectral analysis.
For many clinical applications of proton MR spectroscopic imaging (MRSI) of the brain, diagnostic assessment is limited by insufficient coverage provided by single- or multislice acquisition methods as well as by the use of volume preselection methods. Additionally, traditional spectral analysis methods may limit the operator to detailed analysis of only a few selected brain regions. It is therefore highly desirable to use a fully 3D approach, combined with spectral analysis procedures that enable automated assessment of 3D metabolite distributions over the whole brain. In this study, a 3D echo-planar MRSI technique has been implemented without volume preselection to provide sufficient spatial resolution with maximum coverage of the brain. Using MRSI acquisitions in normal subjects at 1.5T and a fully automated spectral analysis procedure, an assessment of the resultant spectral quality and the extent of viable data in human brain was carried out. The analysis found that 69% of brain voxels were obtained with acceptable spectral quality at TE = 135 ms, and 52% at TE = 25 ms. Most of the rejected voxels were located near the sinuses or temporal bones and demonstrated poor B0 homogeneity and additional regions were affected by stronger lipid contamination at TE = 25 ms.
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- Signal Processing, Computer-Assisted
- Nuclear Medicine & Medical Imaging
- Magnetic Resonance Spectroscopy
- Imaging, Three-Dimensional
- Humans
- Echo-Planar Imaging
- Brain
- 4003 Biomedical engineering
- 0903 Biomedical Engineering
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Signal Processing, Computer-Assisted
- Nuclear Medicine & Medical Imaging
- Magnetic Resonance Spectroscopy
- Imaging, Three-Dimensional
- Humans
- Echo-Planar Imaging
- Brain
- 4003 Biomedical engineering
- 0903 Biomedical Engineering