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Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder.

Publication ,  Journal Article
Deicken, RF; Pegues, MP; Anzalone, S; Feiwell, R; Soher, B
Published in: Am J Psychiatry
May 2003

OBJECTIVE: Previous studies attempting to identify neuropathological alterations in the hippocampus in bipolar disorder have been inconclusive. The objective of this study was to determine if the concentration of N-acetylaspartate, a neuronal and axonal marker, was lower in subjects with familial bipolar I disorder than in healthy comparison subjects, suggesting possible neuronal loss, neuronal dysfunction, or neuropil reduction in bipolar I disorder. METHOD: N-acetylaspartate, choline, and creatine in the right and left hippocampus were measured in 15 euthymic male patients with familial bipolar I disorder and 20 healthy male comparison subjects by using proton magnetic resonance spectroscopy ((1)H-MRS). RESULTS: Relative to the comparison group, the patients with bipolar I disorder demonstrated significantly lower concentrations of N-acetylaspartate and creatine but normal choline concentration in both the right and left hippocampus. There were no group or lateralized differences in the percentages of different tissue types within the MRS voxels, suggesting that the hippocampal N-acetylaspartate and creatine alterations were not an artifact of variations in tissue types represented in the voxels. There was also a significant negative correlation between N-acetylaspartate concentration in the right hippocampus and illness duration, after adjustment for the effects of age. CONCLUSIONS: This preliminary study provides support for the existence of neuronal loss, neuronal metabolic dysfunction, or interneuronal neuropil reduction in the hippocampal region in male patients with familial bipolar I disorder. The finding of normal hippocampal choline levels in these patients does not provide support for ongoing myelin breakdown or glial cell proliferation in this brain region in familial bipolar I disorder. The significant association between illness duration and N-acetylaspartate concentration in the right hippocampus supports the idea that neuronal pathology may increase with disease progression and that this effect may be lateralized, involving the right but not the left hippocampus.

Duke Scholars

Published In

Am J Psychiatry

DOI

ISSN

0002-953X

Publication Date

May 2003

Volume

160

Issue

5

Start / End Page

873 / 882

Location

United States

Related Subject Headings

  • Psychiatry
  • Neurons
  • Middle Aged
  • Male
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Humans
  • Hippocampus
  • Functional Laterality
  • Family
 

Citation

APA
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ICMJE
MLA
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Deicken, R. F., Pegues, M. P., Anzalone, S., Feiwell, R., & Soher, B. (2003). Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder. Am J Psychiatry, 160(5), 873–882. https://doi.org/10.1176/appi.ajp.160.5.873
Deicken, Raymond F., Mary P. Pegues, Susan Anzalone, Robert Feiwell, and Brian Soher. “Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder.Am J Psychiatry 160, no. 5 (May 2003): 873–82. https://doi.org/10.1176/appi.ajp.160.5.873.
Deicken RF, Pegues MP, Anzalone S, Feiwell R, Soher B. Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder. Am J Psychiatry. 2003 May;160(5):873–82.
Deicken, Raymond F., et al. “Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder.Am J Psychiatry, vol. 160, no. 5, May 2003, pp. 873–82. Pubmed, doi:10.1176/appi.ajp.160.5.873.
Deicken RF, Pegues MP, Anzalone S, Feiwell R, Soher B. Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder. Am J Psychiatry. 2003 May;160(5):873–882.
Journal cover image

Published In

Am J Psychiatry

DOI

ISSN

0002-953X

Publication Date

May 2003

Volume

160

Issue

5

Start / End Page

873 / 882

Location

United States

Related Subject Headings

  • Psychiatry
  • Neurons
  • Middle Aged
  • Male
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Humans
  • Hippocampus
  • Functional Laterality
  • Family