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Observation of coupled 1H metabolite resonances at long TE.

Publication ,  Journal Article
Soher, BJ; Pattany, PM; Matson, GB; Maudsley, AA
Published in: Magn Reson Med
June 2005

A PRESS localization (1)H MRS acquisition sequence with a Carr-Purcell train of refocusing pulses (CP-PRESS) has been implemented using global refocusing "sandwich" pulses. The CP pulse train minimized the effects of J-coupled dephasing in metabolites with strongly coupled, multiplet resonance groups as demonstrated in both phantom data and in vivo single-voxel spectroscopy in normal volunteers. Metabolites with multiplet resonance patterns were maintained with greater signal to noise and a simpler resonance pattern at long echo times. T(2) decay times for metabolites with singlet and multiplet resonances were similar to published values, except for the NAA multiplet at 2.5 ppm, which had a significantly shorter T(2) value (147 ms) than that typically reported for the singlet at 2.01 ppm. Metabolite-nulled spectra were acquired in normal volunteers to evaluate the effects of CP-PRESS on baseline signal contributions from residual water, lipids, and macromolecules. The T(2) decay times in four baseline regions in data acquired with the CP-PRESS sequence showed longer decays than corresponding regions in metabolite-nulled spectra from a standard PRESS sequence, but were significantly diminished long before the metabolites of interest were gone. The spectral analysis for spectra with longer TE times also showed less variability due the higher metabolite SNR, simpler spectral patterns, and the decreased baseline contributions.

Duke Scholars

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

June 2005

Volume

53

Issue

6

Start / End Page

1283 / 1287

Location

United States

Related Subject Headings

  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Magnetic Resonance Spectroscopy
  • Inositol
  • Humans
  • Glutamic Acid
  • Creatine
  • Choline
  • Brain Chemistry
 

Citation

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Soher, B. J., Pattany, P. M., Matson, G. B., & Maudsley, A. A. (2005). Observation of coupled 1H metabolite resonances at long TE. Magn Reson Med, 53(6), 1283–1287. https://doi.org/10.1002/mrm.20491
Soher, Brian J., Pradip M. Pattany, Gerald B. Matson, and Andrew A. Maudsley. “Observation of coupled 1H metabolite resonances at long TE.Magn Reson Med 53, no. 6 (June 2005): 1283–87. https://doi.org/10.1002/mrm.20491.
Soher BJ, Pattany PM, Matson GB, Maudsley AA. Observation of coupled 1H metabolite resonances at long TE. Magn Reson Med. 2005 Jun;53(6):1283–7.
Soher, Brian J., et al. “Observation of coupled 1H metabolite resonances at long TE.Magn Reson Med, vol. 53, no. 6, June 2005, pp. 1283–87. Pubmed, doi:10.1002/mrm.20491.
Soher BJ, Pattany PM, Matson GB, Maudsley AA. Observation of coupled 1H metabolite resonances at long TE. Magn Reson Med. 2005 Jun;53(6):1283–1287.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

June 2005

Volume

53

Issue

6

Start / End Page

1283 / 1287

Location

United States

Related Subject Headings

  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Magnetic Resonance Spectroscopy
  • Inositol
  • Humans
  • Glutamic Acid
  • Creatine
  • Choline
  • Brain Chemistry