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Robust analysis of short echo time (1)H MRSI of human brain.

Publication ,  Journal Article
Zhu, XP; Young, K; Ebel, A; Soher, BJ; Kaiser, L; Matson, G; Weiner, WM; Schuff, N
Published in: Magn Reson Med
March 2006

Short echo time proton MR Spectroscopic Imaging (MRSI) suffers from low signal-to-noise ratio (SNR), limiting accuracy to estimate metabolite intensities. A method to coherently sum spectra in a region of interest of the human brain by appropriate peak alignment was developed to yield a mean spectrum with increased SNR. Furthermore, principal component (PC) spectra were calculated to estimate the variance of the mean spectrum. The mean or alternatively the first PC (PC(1)) spectrum from the same region can be used for quantitation of peak areas of metabolites in the human brain at increased SNR. Monte Carlo simulations showed that both mean and PC(1) spectra were more accurate in estimating regional metabolite concentrations than solutions that regress individual spectra against the tissue compositions of MRSI voxels. Back-to-back MRSI studies on 10 healthy volunteers showed that mean spectra markedly improved reliability of brain metabolite measurements, most notably for myo-inositol, as compared to regression methods.

Duke Scholars

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

March 2006

Volume

55

Issue

3

Start / End Page

706 / 711

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Magnetic Resonance Spectroscopy
  • Inositol
  • Humans
  • Brain Chemistry
  • Aged
  • Adult
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering
 

Citation

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Zhu, X. P., Young, K., Ebel, A., Soher, B. J., Kaiser, L., Matson, G., … Schuff, N. (2006). Robust analysis of short echo time (1)H MRSI of human brain. Magn Reson Med, 55(3), 706–711. https://doi.org/10.1002/mrm.20805
Zhu, X. P., K. Young, A. Ebel, B. J. Soher, L. Kaiser, G. Matson, W. M. Weiner, and N. Schuff. “Robust analysis of short echo time (1)H MRSI of human brain.Magn Reson Med 55, no. 3 (March 2006): 706–11. https://doi.org/10.1002/mrm.20805.
Zhu XP, Young K, Ebel A, Soher BJ, Kaiser L, Matson G, et al. Robust analysis of short echo time (1)H MRSI of human brain. Magn Reson Med. 2006 Mar;55(3):706–11.
Zhu, X. P., et al. “Robust analysis of short echo time (1)H MRSI of human brain.Magn Reson Med, vol. 55, no. 3, Mar. 2006, pp. 706–11. Pubmed, doi:10.1002/mrm.20805.
Zhu XP, Young K, Ebel A, Soher BJ, Kaiser L, Matson G, Weiner WM, Schuff N. Robust analysis of short echo time (1)H MRSI of human brain. Magn Reson Med. 2006 Mar;55(3):706–711.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

March 2006

Volume

55

Issue

3

Start / End Page

706 / 711

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Magnetic Resonance Spectroscopy
  • Inositol
  • Humans
  • Brain Chemistry
  • Aged
  • Adult
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering