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Reproducibility of 3D proton spectroscopy in the human brain.

Publication ,  Journal Article
Li, BSY; Babb, JS; Soher, BJ; Maudsley, AA; Gonen, O
Published in: Magn Reson Med
March 2002

The inter- and intrasubject reproducibility of the metabolite levels of N-acetylaspartate (NAA), creatine (Cr), and choline (Cho), obtained with three-dimensional (3D) multivoxel proton spectroscopy (1H-MRS), was analyzed in eight healthy volunteers. Serial, back-to-back measurements on a phantom showed the methodology and instrumentation to be highly reproducible, with a median coefficient of variation (CV) of 3.8%. In the human brain, the metabolite levels' variability was larger, with intrasubject median CVs for a total of 1876 signal voxels of 13.8%, 18.5%, and 20.1% for NAA, Cr, and Cho, respectively. These variations possibly arise from small, unavoidable, +/-1-2 mm volume-of-interest (VOI) repositioning uncertainties, which vary each 0.75-cm(3) voxel's partial fluid/gray/white-matter fractions. Comparing the CVs between eight subjects in a total of 324 selected voxels gave total interindividual CVs of 15.6%, 23.3%, and 24.4%, compared with intraindividual CVs in the same voxels of 14.4%, 14.8%, and 15.3%, for NAA, Cr, and Cho, respectively. Replacing the signal(s) from each voxel by the average of itself with its six canonical neighbors reduces the intrasubject median CVs to 8.3%, 9.5%, and 9.7%. The measurement uncertainties can be reduced at a cost of either spatial resolution (by using larger voxels) or time (by performing serial follow-ups).

Duke Scholars

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

March 2002

Volume

47

Issue

3

Start / End Page

439 / 446

Location

United States

Related Subject Headings

  • Reproducibility of Results
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Spectroscopy
  • Imaging, Three-Dimensional
  • Image Processing, Computer-Assisted
  • Humans
  • Female
 

Citation

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ICMJE
MLA
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Li, B. S. Y., Babb, J. S., Soher, B. J., Maudsley, A. A., & Gonen, O. (2002). Reproducibility of 3D proton spectroscopy in the human brain. Magn Reson Med, 47(3), 439–446. https://doi.org/10.1002/mrm.10081
Li, Belinda S. Y., James S. Babb, Brian J. Soher, Andrew A. Maudsley, and Oded Gonen. “Reproducibility of 3D proton spectroscopy in the human brain.Magn Reson Med 47, no. 3 (March 2002): 439–46. https://doi.org/10.1002/mrm.10081.
Li BSY, Babb JS, Soher BJ, Maudsley AA, Gonen O. Reproducibility of 3D proton spectroscopy in the human brain. Magn Reson Med. 2002 Mar;47(3):439–46.
Li, Belinda S. Y., et al. “Reproducibility of 3D proton spectroscopy in the human brain.Magn Reson Med, vol. 47, no. 3, Mar. 2002, pp. 439–46. Pubmed, doi:10.1002/mrm.10081.
Li BSY, Babb JS, Soher BJ, Maudsley AA, Gonen O. Reproducibility of 3D proton spectroscopy in the human brain. Magn Reson Med. 2002 Mar;47(3):439–446.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

March 2002

Volume

47

Issue

3

Start / End Page

439 / 446

Location

United States

Related Subject Headings

  • Reproducibility of Results
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Spectroscopy
  • Imaging, Three-Dimensional
  • Image Processing, Computer-Assisted
  • Humans
  • Female