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Regional metabolite T2 in the healthy rhesus macaque brain at 7T.

Publication ,  Journal Article
Liu, S; Gonen, O; Fleysher, L; Fleysher, R; Soher, BJ; Pilkenton, S; Lentz, MR; Ratai, E-M; González, RG
Published in: Magn Reson Med
May 2008

Although the rhesus macaque brain is an excellent model system for the study of neurological diseases and their responses to treatment, its small size requires much higher spatial resolution, motivating use of ultra-high-field (B(0)) imagers. Their weaker radio-frequency fields, however, dictate longer pulses; hence longer TE localization sequences. Due to the shorter transverse relaxation time (T(2)) at higher B(0)s, these longer TEs subject metabolites to T(2)-weighting, that decrease their quantification accuracy. To address this we measured the T(2)s of N-acetylaspartate (NAA), choline (Cho), and creatine (Cr) in several gray matter (GM) and white matter (WM) regions of four healthy rhesus macaques at 7T using three-dimensional (3D) proton MR spectroscopic imaging at (0.4 cm)(3) = 64 mul spatial resolution. The results show that macaque T(2)s are in good agreement with those reported in humans at 7T: 169 +/- 2.3 ms for NAA (mean +/- SEM), 114 +/- 1.9 ms for Cr, and 128 +/- 2.4 ms for Cho, with no significant differences between GM and WM. The T(2) histograms from 320 voxels in each animal for NAA, Cr, and Cho were similar in position and shape, indicating that they are potentially characteristic of "healthy" in this species.

Duke Scholars

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

May 2008

Volume

59

Issue

5

Start / End Page

1165 / 1169

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Spectroscopy
  • Macaca mulatta
  • Image Processing, Computer-Assisted
  • Female
  • Creatine
  • Choline
  • Brain Mapping
  • Brain
 

Citation

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MLA
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Liu, S., Gonen, O., Fleysher, L., Fleysher, R., Soher, B. J., Pilkenton, S., … González, R. G. (2008). Regional metabolite T2 in the healthy rhesus macaque brain at 7T. Magn Reson Med, 59(5), 1165–1169. https://doi.org/10.1002/mrm.21574
Liu, Songtao, Oded Gonen, Lazar Fleysher, Roman Fleysher, Brian J. Soher, Sarah Pilkenton, Margaret R. Lentz, Eva-Maria Ratai, and R Gilberto González. “Regional metabolite T2 in the healthy rhesus macaque brain at 7T.Magn Reson Med 59, no. 5 (May 2008): 1165–69. https://doi.org/10.1002/mrm.21574.
Liu S, Gonen O, Fleysher L, Fleysher R, Soher BJ, Pilkenton S, et al. Regional metabolite T2 in the healthy rhesus macaque brain at 7T. Magn Reson Med. 2008 May;59(5):1165–9.
Liu, Songtao, et al. “Regional metabolite T2 in the healthy rhesus macaque brain at 7T.Magn Reson Med, vol. 59, no. 5, May 2008, pp. 1165–69. Pubmed, doi:10.1002/mrm.21574.
Liu S, Gonen O, Fleysher L, Fleysher R, Soher BJ, Pilkenton S, Lentz MR, Ratai E-M, González RG. Regional metabolite T2 in the healthy rhesus macaque brain at 7T. Magn Reson Med. 2008 May;59(5):1165–1169.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

May 2008

Volume

59

Issue

5

Start / End Page

1165 / 1169

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Spectroscopy
  • Macaca mulatta
  • Image Processing, Computer-Assisted
  • Female
  • Creatine
  • Choline
  • Brain Mapping
  • Brain