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Metabolite proton T(2) mapping in the healthy rhesus macaque brain at 3 T.

Publication ,  Journal Article
Liu, S; Gonen, O; Fleysher, R; Fleysher, L; Babb, JS; Soher, BJ; Joo, C-G; Ratai, E-M; González, RG
Published in: Magn Reson Med
November 2009

The structure and metabolism of the rhesus macaque brain, an advanced model for neurologic diseases and their treatment response, is often studied noninvasively with MRI and (1)H-MR spectroscopy. Due to the shorter transverse relaxation time (T(2)) at the higher magnetic fields these studies favor, the echo times used in (1)H-MR spectroscopy subject the metabolites to unknown T(2) weighting, decreasing the accuracy of quantification which is key for inter- and intra-animal comparisons. To establish the "baseline" (healthy animal) T(2) values, we mapped them for the three main metabolites' T(2)s at 3 T in four healthy rhesus macaques and tested the hypotheses that their mean values are similar (i) among animals; and (ii) to analogs regions in the human brain. This was done with three-dimensional multivoxel (1)H-MR spectroscopy at (0.6 x 0.6 x 0.5 cm)(3) = 180 microL spatial resolution over a 4.2 x 3.0 x 2.0 = 25 cm(3) ( approximately 30%) of the macaque brain in a two-point protocol that optimizes T(2) precision per unit time. The estimated T(2)s in several gray and white matter regions are all within 10% of those reported in the human brain (mean +/- standard error of the mean): N-acetylaspartate = 316 +/- 7, creatine = 177 +/- 3, and choline = 264 +/- 9 ms, with no statistically significant gray versus white matter differences.

Duke Scholars

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

November 2009

Volume

62

Issue

5

Start / End Page

1292 / 1299

Location

United States

Related Subject Headings

  • Tissue Distribution
  • Protons
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Macaca mulatta
  • Female
  • Choline
  • Brain
  • Aspartic Acid
 

Citation

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Liu, S., Gonen, O., Fleysher, R., Fleysher, L., Babb, J. S., Soher, B. J., … González, R. G. (2009). Metabolite proton T(2) mapping in the healthy rhesus macaque brain at 3 T. Magn Reson Med, 62(5), 1292–1299. https://doi.org/10.1002/mrm.22117
Liu, Songtao, Oded Gonen, Roman Fleysher, Lazar Fleysher, James S. Babb, Brian J. Soher, Chan-Gyu Joo, Eva-Maria Ratai, and R Gilberto González. “Metabolite proton T(2) mapping in the healthy rhesus macaque brain at 3 T.Magn Reson Med 62, no. 5 (November 2009): 1292–99. https://doi.org/10.1002/mrm.22117.
Liu S, Gonen O, Fleysher R, Fleysher L, Babb JS, Soher BJ, et al. Metabolite proton T(2) mapping in the healthy rhesus macaque brain at 3 T. Magn Reson Med. 2009 Nov;62(5):1292–9.
Liu, Songtao, et al. “Metabolite proton T(2) mapping in the healthy rhesus macaque brain at 3 T.Magn Reson Med, vol. 62, no. 5, Nov. 2009, pp. 1292–99. Pubmed, doi:10.1002/mrm.22117.
Liu S, Gonen O, Fleysher R, Fleysher L, Babb JS, Soher BJ, Joo C-G, Ratai E-M, González RG. Metabolite proton T(2) mapping in the healthy rhesus macaque brain at 3 T. Magn Reson Med. 2009 Nov;62(5):1292–1299.
Journal cover image

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

November 2009

Volume

62

Issue

5

Start / End Page

1292 / 1299

Location

United States

Related Subject Headings

  • Tissue Distribution
  • Protons
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Macaca mulatta
  • Female
  • Choline
  • Brain
  • Aspartic Acid