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Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging.

Publication ,  Journal Article
Zhu, X; Schuff, N; Kornak, J; Soher, B; Yaffe, K; Kramer, JH; Ezekiel, F; Miller, BL; Jagust, WJ; Weiner, MW
Published in: Alzheimer Dis Assoc Disord
2006

Previous magnetic resonance (MR) spectroscopy studies of Alzheimer disease (AD) reporting reduced N-acetyl aspartate (NAA) and increased myo-Inositol (mI) used single voxel techniques, which have limited ability to assess the regional distribution of the metabolite abnormalities. The objective of this study was to determine the regional distribution of NAA and mI alterations in AD by using MR spectroscopic imaging. Fourteen patients with AD and 22 cognitively normal elderly were studied using structural MR imaging and MR spectroscopic imaging. Changes of NAA, mI, and various metabolite ratios were measured in frontal and parietal lobe gray matter (GM) and white matter. This study found: (1) when compared with cognitively normal subjects, AD patients had increased mI and mI/creatine (Cr) ratios primarily in parietal lobe GM, whereas frontal lobe GM and white matter were spared; (2) in the same region where mI was increased, AD patients had also decreased NAA and NAA/Cr ratios, replicating previous findings; (3) however, increased mI or mI/Cr ratios did not correlate with decreased NAA or NAA/Cr ratios; and (4) using mI/Cr and NAA/Cr together improved sensitivity and specificity to AD from control as compared with NAA/Cr alone. In conclusion, decreased NAA and increased mI in AD are primarily localized in parietal lobe GM regions. However, the NAA and mI changes are not correlated with each other, suggesting that they represent different processes that might help staging of AD.

Duke Scholars

Published In

Alzheimer Dis Assoc Disord

DOI

ISSN

0893-0341

Publication Date

2006

Volume

20

Issue

2

Start / End Page

77 / 85

Location

United States

Related Subject Headings

  • Statistics as Topic
  • Reference Values
  • Parietal Lobe
  • Neuropsychological Tests
  • Middle Aged
  • Mental Status Schedule
  • Male
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Inositol
 

Citation

APA
Chicago
ICMJE
MLA
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Zhu, X., Schuff, N., Kornak, J., Soher, B., Yaffe, K., Kramer, J. H., … Weiner, M. W. (2006). Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging. Alzheimer Dis Assoc Disord, 20(2), 77–85. https://doi.org/10.1097/01.wad.0000213809.12553.fc
Zhu, Xiaoping, Norbert Schuff, John Kornak, Brian Soher, Kristine Yaffe, Joel H. Kramer, Frank Ezekiel, Bruce L. Miller, William J. Jagust, and Michael W. Weiner. “Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging.Alzheimer Dis Assoc Disord 20, no. 2 (2006): 77–85. https://doi.org/10.1097/01.wad.0000213809.12553.fc.
Zhu X, Schuff N, Kornak J, Soher B, Yaffe K, Kramer JH, et al. Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging. Alzheimer Dis Assoc Disord. 2006;20(2):77–85.
Zhu, Xiaoping, et al. “Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging.Alzheimer Dis Assoc Disord, vol. 20, no. 2, 2006, pp. 77–85. Pubmed, doi:10.1097/01.wad.0000213809.12553.fc.
Zhu X, Schuff N, Kornak J, Soher B, Yaffe K, Kramer JH, Ezekiel F, Miller BL, Jagust WJ, Weiner MW. Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging. Alzheimer Dis Assoc Disord. 2006;20(2):77–85.

Published In

Alzheimer Dis Assoc Disord

DOI

ISSN

0893-0341

Publication Date

2006

Volume

20

Issue

2

Start / End Page

77 / 85

Location

United States

Related Subject Headings

  • Statistics as Topic
  • Reference Values
  • Parietal Lobe
  • Neuropsychological Tests
  • Middle Aged
  • Mental Status Schedule
  • Male
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Inositol