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Comprehensive analysis of the Cramer-Rao bounds for magnetic resonance temperature change measurement in fat-water voxels using multi-echo imaging.

Publication ,  Journal Article
Wyatt, C; Soher, BJ; Arunachalam, K; MacFall, J
Published in: MAGMA
February 2012

OBJECT: The aim of this paper is to characterize the noise propagation for MRI temperature change measurement with emphasis on finding the best echo time combinations that yield the lowest temperature noise. MATERIALS AND METHODS: A Cramer-Rao lower-bound (CRLB) calculation was used to estimate the temperature noise for a model of the MR signal in fat-water voxels. The temperature noise CRLB was then used to find a set of echo times that gave the lowest temperature change noise for a range of fat-water frequency differences, temperature changes, fat/water signal ratios, and T2* values. CRLB estimates were verified by Monte Carlo simulation and in phantoms using images acquired in a 1.5 T magnet. RESULTS: Results show that regions exist where the CRLB predicts minimal temperature variation as a function of the other variables. The results also indicate that the CRLB values calculated in this paper provide excellent guidance for predicting the variation of temperature measurements due to changes in the signal parameters. For three echo scans, the best noise characteristics are seen for TE values of 20.71, 23.71, and 26.71 ms. Results for five and seven echo scans are also presented in the text. CONCLUSION: The results present a comprehensive analysis of the effects of different scan parameters on temperature noise, potentially benefiting the selection of scan parameters for clinical MRI thermometry.

Duke Scholars

Published In

MAGMA

DOI

EISSN

1352-8661

Publication Date

February 2012

Volume

25

Issue

1

Start / End Page

49 / 61

Location

Germany

Related Subject Headings

  • Water
  • Temperature
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Monte Carlo Method
  • Models, Theoretical
  • Models, Statistical
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wyatt, C., Soher, B. J., Arunachalam, K., & MacFall, J. (2012). Comprehensive analysis of the Cramer-Rao bounds for magnetic resonance temperature change measurement in fat-water voxels using multi-echo imaging. MAGMA, 25(1), 49–61. https://doi.org/10.1007/s10334-011-0247-x
Wyatt, Cory, Brian J. Soher, Kavitha Arunachalam, and James MacFall. “Comprehensive analysis of the Cramer-Rao bounds for magnetic resonance temperature change measurement in fat-water voxels using multi-echo imaging.MAGMA 25, no. 1 (February 2012): 49–61. https://doi.org/10.1007/s10334-011-0247-x.
Wyatt, Cory, et al. “Comprehensive analysis of the Cramer-Rao bounds for magnetic resonance temperature change measurement in fat-water voxels using multi-echo imaging.MAGMA, vol. 25, no. 1, Feb. 2012, pp. 49–61. Pubmed, doi:10.1007/s10334-011-0247-x.
Journal cover image

Published In

MAGMA

DOI

EISSN

1352-8661

Publication Date

February 2012

Volume

25

Issue

1

Start / End Page

49 / 61

Location

Germany

Related Subject Headings

  • Water
  • Temperature
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Monte Carlo Method
  • Models, Theoretical
  • Models, Statistical
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted