Acute stroke: evaluation with serial proton MR spectroscopic imaging.
PURPOSE: To investigate the evolution of metabolic changes detectable with proton magnetic resonance (MR) spectroscopic imaging in acute stroke and to compare these findings with those of conventional MR imaging. MATERIALS AND METHODS: A patient with middle cerebral artery stroke underwent conventional proton-density (PD)- and T2-weighted MR imaging, MR angiography, and multisection proton two-dimensional MR spectroscopic imaging over a period of 3 hours to 5 months after symptom onset. RESULTS: On 3-hour MR images, no abnormal signal intensity change was detectable. Spectroscopic images obtained at 24 hours showed localized elevation of cerebral lactate levels. In most regions with high lactate levels, infarction subsequently occurred. In the chronic stage (5 months), the infarct was associated with reduced N-acetylaspartate levels, increased choline levels, and absence of lactate. CONCLUSION: Spectroscopic imaging enables mapping of ischemic and infarcted brain regions with greater sensitivity than does conventional MR imaging.
Duke Scholars
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- Nuclear Medicine & Medical Imaging
- Middle Aged
- Male
- Magnetic Resonance Spectroscopy
- Magnetic Resonance Imaging
- Lactates
- Humans
- Cerebrovascular Disorders
- Brain Chemistry
- Brain
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Nuclear Medicine & Medical Imaging
- Middle Aged
- Male
- Magnetic Resonance Spectroscopy
- Magnetic Resonance Imaging
- Lactates
- Humans
- Cerebrovascular Disorders
- Brain Chemistry
- Brain