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Acute stroke: evaluation with serial proton MR spectroscopic imaging.

Publication ,  Journal Article
Barker, PB; Gillard, JH; van Zijl, PC; Soher, BJ; Hanley, DF; Agildere, AM; Oppenheimer, SM; Bryan, RN
Published in: Radiology
September 1994

PURPOSE: To investigate the evolution of metabolic changes detectable with proton magnetic resonance (MR) spectroscopic imaging in acute stroke and to compare these findings with those of conventional MR imaging. MATERIALS AND METHODS: A patient with middle cerebral artery stroke underwent conventional proton-density (PD)- and T2-weighted MR imaging, MR angiography, and multisection proton two-dimensional MR spectroscopic imaging over a period of 3 hours to 5 months after symptom onset. RESULTS: On 3-hour MR images, no abnormal signal intensity change was detectable. Spectroscopic images obtained at 24 hours showed localized elevation of cerebral lactate levels. In most regions with high lactate levels, infarction subsequently occurred. In the chronic stage (5 months), the infarct was associated with reduced N-acetylaspartate levels, increased choline levels, and absence of lactate. CONCLUSION: Spectroscopic imaging enables mapping of ischemic and infarcted brain regions with greater sensitivity than does conventional MR imaging.

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Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

September 1994

Volume

192

Issue

3

Start / End Page

723 / 732

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Lactates
  • Humans
  • Cerebrovascular Disorders
  • Brain Chemistry
  • Brain
 

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Barker, P. B., Gillard, J. H., van Zijl, P. C., Soher, B. J., Hanley, D. F., Agildere, A. M., … Bryan, R. N. (1994). Acute stroke: evaluation with serial proton MR spectroscopic imaging. Radiology, 192(3), 723–732. https://doi.org/10.1148/radiology.192.3.8058940
Barker, P. B., J. H. Gillard, P. C. van Zijl, B. J. Soher, D. F. Hanley, A. M. Agildere, S. M. Oppenheimer, and R. N. Bryan. “Acute stroke: evaluation with serial proton MR spectroscopic imaging.Radiology 192, no. 3 (September 1994): 723–32. https://doi.org/10.1148/radiology.192.3.8058940.
Barker PB, Gillard JH, van Zijl PC, Soher BJ, Hanley DF, Agildere AM, et al. Acute stroke: evaluation with serial proton MR spectroscopic imaging. Radiology. 1994 Sep;192(3):723–32.
Barker, P. B., et al. “Acute stroke: evaluation with serial proton MR spectroscopic imaging.Radiology, vol. 192, no. 3, Sept. 1994, pp. 723–32. Pubmed, doi:10.1148/radiology.192.3.8058940.
Barker PB, Gillard JH, van Zijl PC, Soher BJ, Hanley DF, Agildere AM, Oppenheimer SM, Bryan RN. Acute stroke: evaluation with serial proton MR spectroscopic imaging. Radiology. 1994 Sep;192(3):723–732.
Journal cover image

Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

September 1994

Volume

192

Issue

3

Start / End Page

723 / 732

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Lactates
  • Humans
  • Cerebrovascular Disorders
  • Brain Chemistry
  • Brain