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Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain: metabolite distributions and reliability.

Publication ,  Journal Article
Wiedermann, D; Schuff, N; Matson, GB; Soher, BJ; Du, AT; Maudsley, AA; Weiner, MW
Published in: Magn Reson Imaging
October 2001

Multislice proton magnetic resonance spectroscopic imaging (1H MRSI) at 25 ms echo time was used to measure concentrations of myo-inositol (mI), N-acetylaspartate (NAA), and creatine (Cr) and choline (Cho) in ten normal subjects between 22 and 84 years of age (mean age 44 +/- 18 years). By co-analysis with MRI based tissue segmentation results, metabolite distributions were analyzed for each tissue type and for different brain regions. Measurement reliability was evaluated using intraclass correlation coefficients (ICC). Significant differences in metabolite distributions were found for all metabolites. mI of frontal gray matter was 84% of parietal gray matter and 87% of white matter. NAA of frontal gray matter was 86% of parietal gray matter and 85% of white matter. Cho of frontal gray matter was 125% of parietal gray matter and 59% of white matter and Cho of parietal gray matter was 47% of white matter. Cr of parietal gray matter was 113% of white matter. Reliability was relatively high (ICC from.70 to.93) for all metabolites in white matter and for NAA and Cr in gray matter, though limited (ICC less than.63) for mI and Cho in gray matter. These findings indicate that voxel gray/white matter contributions, regional variations in metabolite concentrations, and reliability limitations must be considered when interpreting 1H MR spectra of the brain.

Duke Scholars

Published In

Magn Reson Imaging

DOI

ISSN

0730-725X

Publication Date

October 2001

Volume

19

Issue

8

Start / End Page

1073 / 1080

Location

Netherlands

Related Subject Headings

  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Spectroscopy
  • Linear Models
  • Inositol
  • Humans
  • Female
  • Creatine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wiedermann, D., Schuff, N., Matson, G. B., Soher, B. J., Du, A. T., Maudsley, A. A., & Weiner, M. W. (2001). Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain: metabolite distributions and reliability. Magn Reson Imaging, 19(8), 1073–1080. https://doi.org/10.1016/s0730-725x(01)00441-6
Wiedermann, D., N. Schuff, G. B. Matson, B. J. Soher, A. T. Du, A. A. Maudsley, and M. W. Weiner. “Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain: metabolite distributions and reliability.Magn Reson Imaging 19, no. 8 (October 2001): 1073–80. https://doi.org/10.1016/s0730-725x(01)00441-6.
Wiedermann D, Schuff N, Matson GB, Soher BJ, Du AT, Maudsley AA, et al. Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain: metabolite distributions and reliability. Magn Reson Imaging. 2001 Oct;19(8):1073–80.
Wiedermann, D., et al. “Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain: metabolite distributions and reliability.Magn Reson Imaging, vol. 19, no. 8, Oct. 2001, pp. 1073–80. Pubmed, doi:10.1016/s0730-725x(01)00441-6.
Wiedermann D, Schuff N, Matson GB, Soher BJ, Du AT, Maudsley AA, Weiner MW. Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain: metabolite distributions and reliability. Magn Reson Imaging. 2001 Oct;19(8):1073–1080.
Journal cover image

Published In

Magn Reson Imaging

DOI

ISSN

0730-725X

Publication Date

October 2001

Volume

19

Issue

8

Start / End Page

1073 / 1080

Location

Netherlands

Related Subject Headings

  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Spectroscopy
  • Linear Models
  • Inositol
  • Humans
  • Female
  • Creatine