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Heterogeneity of stimulant dependence: a national drug abuse treatment clinical trials network study.

Publication ,  Journal Article
Wu, L-T; Blazer, DG; Patkar, AA; Stitzer, ML; Wakim, PG; Brooner, RK
Published in: Am J Addict
2009

We investigated the presence of DSM-IV subtyping for dependence on cocaine and amphetamines (with versus without physical dependence) among outpatient stimulant users enrolled in a multisite study of the Clinical Trials Network (CTN). Three mutually exclusive groups were identified: primary cocaine users (n = 287), primary amphetamine users (n = 99), and dual users (cocaine and amphetamines; n = 29). Distinct subtypes were examined with latent class and logistic regression procedures. Cocaine users were distinct from amphetamine users in age and race/ethnicity. There were four distinct classes of primary cocaine users: non-dependence (15%), compulsive use (14%), tolerance and compulsive use (15%), and physiological dependence (tolerance, withdrawal, and compulsive use; 56%). Three distinct classes of primary amphetamine users were identified: non-dependence (11%), intermediate physiological dependence (31%), and physiological dependence (58%). Regardless of stimulants used, most female users were in the most severe or the physiological dependence group. These results lend support for subtyping dependence in the emerging DSM-V.

Duke Scholars

Published In

Am J Addict

DOI

EISSN

1521-0391

Publication Date

2009

Volume

18

Issue

3

Start / End Page

206 / 218

Location

England

Related Subject Headings

  • Substance Withdrawal Syndrome
  • Substance Abuse
  • Sex Distribution
  • Severity of Illness Index
  • Models, Psychological
  • Male
  • Humans
  • Female
  • Drug Tolerance
  • Diagnostic and Statistical Manual of Mental Disorders
 

Citation

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Wu, L.-T., Blazer, D. G., Patkar, A. A., Stitzer, M. L., Wakim, P. G., & Brooner, R. K. (2009). Heterogeneity of stimulant dependence: a national drug abuse treatment clinical trials network study. Am J Addict, 18(3), 206–218. https://doi.org/10.1080/10550490902787031
Wu, Li-Tzy, Dan G. Blazer, Ashwin A. Patkar, Maxine L. Stitzer, Paul G. Wakim, and Robert K. Brooner. “Heterogeneity of stimulant dependence: a national drug abuse treatment clinical trials network study.Am J Addict 18, no. 3 (2009): 206–18. https://doi.org/10.1080/10550490902787031.
Wu L-T, Blazer DG, Patkar AA, Stitzer ML, Wakim PG, Brooner RK. Heterogeneity of stimulant dependence: a national drug abuse treatment clinical trials network study. Am J Addict. 2009;18(3):206–18.
Wu, Li-Tzy, et al. “Heterogeneity of stimulant dependence: a national drug abuse treatment clinical trials network study.Am J Addict, vol. 18, no. 3, 2009, pp. 206–18. Pubmed, doi:10.1080/10550490902787031.
Wu L-T, Blazer DG, Patkar AA, Stitzer ML, Wakim PG, Brooner RK. Heterogeneity of stimulant dependence: a national drug abuse treatment clinical trials network study. Am J Addict. 2009;18(3):206–218.
Journal cover image

Published In

Am J Addict

DOI

EISSN

1521-0391

Publication Date

2009

Volume

18

Issue

3

Start / End Page

206 / 218

Location

England

Related Subject Headings

  • Substance Withdrawal Syndrome
  • Substance Abuse
  • Sex Distribution
  • Severity of Illness Index
  • Models, Psychological
  • Male
  • Humans
  • Female
  • Drug Tolerance
  • Diagnostic and Statistical Manual of Mental Disorders