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High expression of tumor necrosis factor-related apoptosis-inducing ligand is associated with favorable ovarian cancer survival.

Publication ,  Journal Article
Lancaster, JM; Sayer, R; Blanchette, C; Calingaert, B; Whitaker, R; Schildkraut, J; Marks, J; Berchuck, A
Published in: Clin Cancer Res
February 2003

PURPOSE: The molecular determinants of survival in ovarian cancer are poorly understood. Using expression microarrays, we recently found that high expression of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene is associated with prolonged survival in advanced ovarian cancer. TRAIL has also been shown to synergize with chemotherapeutic agents to induce apoptosis in ovarian cancer cell lines. We therefore sought to confirm the association between TRAIL expression and survival in a larger group of women with ovarian cancer. EXPERIMENTAL DESIGN: TRAIL expression was measured using quantitative real-time PCR in 120 epithelial ovarian cancers (11 stage I/II, 109 stage III/IV) and 8 normal ovarian surface epithelial samples. RESULTS: Ovarian cancers demonstrated 10-fold higher mean TRAIL expression than normal ovarian epithelial samples (P < 0.001). Among ovarian cancers, high TRAIL expression was associated with prolonged survival and was 2.2-fold higher in cancers from patients who lived more than 5 years compared with patients who died within 1 year (P = 0.03). CONCLUSIONS: TRAIL expression is higher in ovarian cancers relative to normal ovarian epithelium. High TRAIL expression is associated with favorable ovarian cancer survival, which may be attributable to increased chemosensitivity of cancers that express the most TRAIL. The use of TRAIL to enhance sensitivity of ovarian cancers to therapy represents an appealing molecular therapeutic strategy worthy of further investigation.

Duke Scholars

Published In

Clin Cancer Res

ISSN

1078-0432

Publication Date

February 2003

Volume

9

Issue

2

Start / End Page

762 / 766

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Time Factors
  • TNF-Related Apoptosis-Inducing Ligand
  • Survival Analysis
  • Reverse Transcriptase Polymerase Chain Reaction
  • Polymerase Chain Reaction
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Membrane Glycoproteins
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lancaster, J. M., Sayer, R., Blanchette, C., Calingaert, B., Whitaker, R., Schildkraut, J., … Berchuck, A. (2003). High expression of tumor necrosis factor-related apoptosis-inducing ligand is associated with favorable ovarian cancer survival. Clin Cancer Res, 9(2), 762–766.
Lancaster, Johnathan M., Robyn Sayer, Carrie Blanchette, Brian Calingaert, Regina Whitaker, Joellen Schildkraut, Jeffrey Marks, and Andrew Berchuck. “High expression of tumor necrosis factor-related apoptosis-inducing ligand is associated with favorable ovarian cancer survival.Clin Cancer Res 9, no. 2 (February 2003): 762–66.
Lancaster JM, Sayer R, Blanchette C, Calingaert B, Whitaker R, Schildkraut J, et al. High expression of tumor necrosis factor-related apoptosis-inducing ligand is associated with favorable ovarian cancer survival. Clin Cancer Res. 2003 Feb;9(2):762–6.
Lancaster, Johnathan M., et al. “High expression of tumor necrosis factor-related apoptosis-inducing ligand is associated with favorable ovarian cancer survival.Clin Cancer Res, vol. 9, no. 2, Feb. 2003, pp. 762–66.
Lancaster JM, Sayer R, Blanchette C, Calingaert B, Whitaker R, Schildkraut J, Marks J, Berchuck A. High expression of tumor necrosis factor-related apoptosis-inducing ligand is associated with favorable ovarian cancer survival. Clin Cancer Res. 2003 Feb;9(2):762–766.

Published In

Clin Cancer Res

ISSN

1078-0432

Publication Date

February 2003

Volume

9

Issue

2

Start / End Page

762 / 766

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Time Factors
  • TNF-Related Apoptosis-Inducing Ligand
  • Survival Analysis
  • Reverse Transcriptase Polymerase Chain Reaction
  • Polymerase Chain Reaction
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Membrane Glycoproteins