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Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis.

Publication ,  Journal Article
Pearce, CL; Wu, AH; Gayther, SA; Bale, AE; Australian Cancer Study (Ovarian Cancer) and Australian Cancer Study Group, ; Beck, PA; Beesley, J ...
Published in: Br J Cancer
January 29, 2008

There is evidence that progesterone plays a role in the aetiology of invasive epithelial ovarian cancer. Therefore, genes involved in pathways that regulate progesterone may be candidates for susceptibility to this disease. Previous studies have suggested that genetic variants in the progesterone receptor gene (PGR) may be associated with ovarian cancer risk, although results have been inconsistent. We have established an international consortium to pool resources and data from many ovarian cancer case-control studies in an effort to identify variants that influence risk. In this study, three PGR single nucleotide polymorphisms (SNPs), for which previous data have suggested they affect ovarian cancer risk, were examined. These were +331 C/T (rs10895068), PROGINS (rs1042838), and a 3' variant (rs608995). A total of 4788 ovarian cancer cases and 7614 controls from 12 case-control studies were included in this analysis. Unconditional logistic regression was used to model the association between each SNP and ovarian cancer risk and two-sided P-values are reported. Overall, risk of ovarian cancer was not associated with any of the three variants studied. However, in histopathological subtype analyses, we found a statistically significant association between risk of endometrioid ovarian cancer and the PROGINS allele (n=651, OR=1.17, 95% CI=1.01-1.36, P=0.036). We also observed borderline evidence of an association between risk of endometrioid ovarian cancer and the +331C/T variant (n=725 cases; OR=0.80, 95% CI 0.62-1.04, P=0.100). These data suggest that while these three variants in the PGR are not associated with ovarian cancer overall, the PROGINS variant may play a modest role in risk of endometrioid ovarian cancer.

Duke Scholars

Published In

Br J Cancer

DOI

ISSN

0007-0920

Publication Date

January 29, 2008

Volume

98

Issue

2

Start / End Page

282 / 288

Location

England

Related Subject Headings

  • Risk Factors
  • Receptors, Progesterone
  • Polymorphism, Single Nucleotide
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Invasiveness
  • Mutagenesis, Insertional
  • Middle Aged
  • Humans
  • Genetic Predisposition to Disease
 

Citation

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Pearce, C. L., Wu, A. H., Gayther, S. A., Bale, A. E., Australian Cancer Study (Ovarian Cancer) and Australian Cancer Study Group, ., Beck, P. A., … Ovarian Cancer Association Consortium, . (2008). Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis. Br J Cancer, 98(2), 282–288. https://doi.org/10.1038/sj.bjc.6604170
Pearce, C. L., A. H. Wu, S. A. Gayther, A. E. Bale, A. E. Australian Cancer Study (Ovarian Cancer) and Australian Cancer Study Group, P. A. Beck, J. Beesley, et al. “Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis.Br J Cancer 98, no. 2 (January 29, 2008): 282–88. https://doi.org/10.1038/sj.bjc.6604170.
Pearce CL, Wu AH, Gayther SA, Bale AE, Australian Cancer Study (Ovarian Cancer) and Australian Cancer Study Group, Beck PA, et al. Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis. Br J Cancer. 2008 Jan 29;98(2):282–8.
Pearce CL, Wu AH, Gayther SA, Bale AE, Australian Cancer Study (Ovarian Cancer) and Australian Cancer Study Group, Beck PA, Beesley J, Chanock S, Cramer DW, DiCioccio R, Edwards R, Fredericksen ZS, Garcia-Closas M, Goode EL, Green AC, Hartmann LC, Hogdall E, Kjaer SK, Lissowska J, McGuire V, Modugno F, Moysich K, Ness RB, Ramus SJ, Risch HA, Sellers TA, Song H, Stram DO, Terry KL, Webb PM, Whiteman DC, Whittemore AS, Zheng W, Pharoah PDP, Chenevix-Trench G, Pike MC, Schildkraut J, Berchuck A, Ovarian Cancer Association Consortium. Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis. Br J Cancer. 2008 Jan 29;98(2):282–288.

Published In

Br J Cancer

DOI

ISSN

0007-0920

Publication Date

January 29, 2008

Volume

98

Issue

2

Start / End Page

282 / 288

Location

England

Related Subject Headings

  • Risk Factors
  • Receptors, Progesterone
  • Polymorphism, Single Nucleotide
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Invasiveness
  • Mutagenesis, Insertional
  • Middle Aged
  • Humans
  • Genetic Predisposition to Disease