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Effects of an oral growth hormone secretagogue in older adults.

Publication ,  Journal Article
White, HK; Petrie, CD; Landschulz, W; MacLean, D; Taylor, A; Lyles, K; Wei, JY; Hoffman, AR; Salvatori, R; Ettinger, MP; Morey, MC ...
Published in: J Clin Endocrinol Metab
April 2009

CONTEXT: GH secretion declines with age, possibly contributing to reduced muscle mass, strength, and function. GH secretagogues (GHS) may increase muscle mass and physical performance. OBJECTIVES/DESIGN: We conducted a randomized, double-masked, placebo-controlled, multicenter study to investigate the hormonal, body composition, and physical performance effects and the safety of the orally active GHS capromorelin in older adults with mild functional limitation. INTERVENTION/PARTICIPANTS: A total of 395 men and women aged 65-84 yr were randomized for an intended 2 yr of treatment to four dosing groups (10 mg three times/week, 3 mg twice a day, 10 mg each night, and 10 mg twice a day) or placebo. Although the study was terminated early according to predetermined treatment effect criteria, 315 subjects completed 6 months of treatment, and 284 completed 12 months. RESULTS: A sustained dose-related rise in IGF-I concentrations occurred in all active treatment groups. Each capromorelin dose prompted a rise in peak nocturnal GH, which was greatest with the least frequent dosing. At 6 months, body weight increased 1.4 kg in subjects receiving capromorelin and decreased 0.2 kg in those receiving placebo (P = 0.006). Lean body mass increased 1.4 vs. 0.3 kg (P = 0.001), and tandem walk improved by 0.9 sec (P = 0.02) in the pooled treatment vs. placebo groups. By 12 months, stair climb also improved (P = 0.04). Adverse events included fatigue, insomnia, and small increases in fasting glucose, glycosylated hemoglobin, and indices of insulin resistance. CONCLUSIONS: In healthy older adults at risk for functional decline, administration of the oral GHS capromorelin may improve body composition and physical function.

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Published In

J Clin Endocrinol Metab

DOI

EISSN

1945-7197

Publication Date

April 2009

Volume

94

Issue

4

Start / End Page

1198 / 1206

Location

United States

Related Subject Headings

  • Safety
  • Pyrazoles
  • Placebos
  • Piperidines
  • Male
  • Insulin-Like Growth Factor I
  • Humans
  • Human Growth Hormone
  • Health Status
  • Female
 

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White, H. K., Petrie, C. D., Landschulz, W., MacLean, D., Taylor, A., Lyles, K., … Capromorelin Study Group, . (2009). Effects of an oral growth hormone secretagogue in older adults. J Clin Endocrinol Metab, 94(4), 1198–1206. https://doi.org/10.1210/jc.2008-0632
White, Heidi K., Charles D. Petrie, William Landschulz, David MacLean, Ann Taylor, Kenneth Lyles, Jeanne Y. Wei, et al. “Effects of an oral growth hormone secretagogue in older adults.J Clin Endocrinol Metab 94, no. 4 (April 2009): 1198–1206. https://doi.org/10.1210/jc.2008-0632.
White HK, Petrie CD, Landschulz W, MacLean D, Taylor A, Lyles K, et al. Effects of an oral growth hormone secretagogue in older adults. J Clin Endocrinol Metab. 2009 Apr;94(4):1198–206.
White, Heidi K., et al. “Effects of an oral growth hormone secretagogue in older adults.J Clin Endocrinol Metab, vol. 94, no. 4, Apr. 2009, pp. 1198–206. Pubmed, doi:10.1210/jc.2008-0632.
White HK, Petrie CD, Landschulz W, MacLean D, Taylor A, Lyles K, Wei JY, Hoffman AR, Salvatori R, Ettinger MP, Morey MC, Blackman MR, Merriam GR, Capromorelin Study Group. Effects of an oral growth hormone secretagogue in older adults. J Clin Endocrinol Metab. 2009 Apr;94(4):1198–1206.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

EISSN

1945-7197

Publication Date

April 2009

Volume

94

Issue

4

Start / End Page

1198 / 1206

Location

United States

Related Subject Headings

  • Safety
  • Pyrazoles
  • Placebos
  • Piperidines
  • Male
  • Insulin-Like Growth Factor I
  • Humans
  • Human Growth Hormone
  • Health Status
  • Female