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A pilot study of atomoxetine in young children with attention-deficit/hyperactivity disorder.

Publication ,  Journal Article
Kratochvil, CJ; Vaughan, BS; Mayfield-Jorgensen, ML; March, JS; Kollins, SH; Murray, DW; Ravi, H; Greenhill, LL; Kotler, LA; Paykina, N ...
Published in: J Child Adolesc Psychopharmacol
April 2007

OBJECTIVE: The purpose of this study was to assess the effectiveness and tolerability of atomoxetine during acute treatment of attention-deficit/hyperactivity disorder (ADHD) in 5 and 6 year olds. METHOD: Twenty two children (male n = 19, 86%) with ADHD were treated with atomoxetine for 8 weeks in a three-site, open-label pilot study. Dosing was flexible, with titration to a maximum of 1.8 mg/kg per day. Parent education on behavior management was provided as part of each pharmacotherapy visit. RESULTS: Subjects demonstrated a mean decrease of 20.68 points (SD = 12.80, p < 0.001)) on the ADHD Rating Scale-IV (ADHD-IV-RS) total score, 10.18 (SD = 7.48, p < 0.001) on the inattentive subscale and 10.50 (SD = 7.04, p < 0.001) on the hyperactive/impulsive subscale. Clinical Global Impression-Severity (CGI-S) was improved in 82% of the children (95% CI, 66-98%) and Children's Global Assessment (CGAS) scores improved 18.91 points on average (SD = 12.20, p < 0.001). The mean final dose of atomoxetine was 1.25 mg/kg per day (SD = 0.35 mg/kg per day). Mood lability was the most commonly reported adverse event (n = 12, 54.5%). Eleven subjects (50%) reported decreased appetite and a mean weight loss of 1.04 kg (SD = 0.80 kg) (p < 0.001) was observed for the group. Vital sign changes were mild and not clinically significant. There were no discontinuations due to adverse events or lack of efficacy. CONCLUSION: Atomoxetine was generally effective for reducing core ADHD symptoms in the 5 and 6 year olds in this open-label study.

Duke Scholars

Published In

J Child Adolesc Psychopharmacol

DOI

ISSN

1044-5463

Publication Date

April 2007

Volume

17

Issue

2

Start / End Page

175 / 185

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Severity of Illness Index
  • Propylamines
  • Pilot Projects
  • Male
  • Humans
  • Female
  • Feasibility Studies
  • Developmental & Child Psychology
  • Child, Preschool
 

Citation

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MLA
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Kratochvil, C. J., Vaughan, B. S., Mayfield-Jorgensen, M. L., March, J. S., Kollins, S. H., Murray, D. W., … Stoner, J. (2007). A pilot study of atomoxetine in young children with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol, 17(2), 175–185. https://doi.org/10.1089/cap.2006.0143
Kratochvil, Christopher J., Brigette S. Vaughan, Michelle L. Mayfield-Jorgensen, John S. March, Scott H. Kollins, Desiree W. Murray, Hima Ravi, et al. “A pilot study of atomoxetine in young children with attention-deficit/hyperactivity disorder.J Child Adolesc Psychopharmacol 17, no. 2 (April 2007): 175–85. https://doi.org/10.1089/cap.2006.0143.
Kratochvil CJ, Vaughan BS, Mayfield-Jorgensen ML, March JS, Kollins SH, Murray DW, et al. A pilot study of atomoxetine in young children with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2007 Apr;17(2):175–85.
Kratochvil, Christopher J., et al. “A pilot study of atomoxetine in young children with attention-deficit/hyperactivity disorder.J Child Adolesc Psychopharmacol, vol. 17, no. 2, Apr. 2007, pp. 175–85. Pubmed, doi:10.1089/cap.2006.0143.
Kratochvil CJ, Vaughan BS, Mayfield-Jorgensen ML, March JS, Kollins SH, Murray DW, Ravi H, Greenhill LL, Kotler LA, Paykina N, Biggins P, Stoner J. A pilot study of atomoxetine in young children with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2007 Apr;17(2):175–185.
Journal cover image

Published In

J Child Adolesc Psychopharmacol

DOI

ISSN

1044-5463

Publication Date

April 2007

Volume

17

Issue

2

Start / End Page

175 / 185

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Severity of Illness Index
  • Propylamines
  • Pilot Projects
  • Male
  • Humans
  • Female
  • Feasibility Studies
  • Developmental & Child Psychology
  • Child, Preschool