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Risk factors for infective endocarditis in patients with enterococcal bacteremia: a case-control study.

Publication ,  Journal Article
Anderson, DJ; Murdoch, DR; Sexton, DJ; Reller, LB; Stout, JE; Cabell, CH; Corey, GR
Published in: Infection
April 2004

BACKGROUND: Based on previous studies, enterococcal infective endocarditis (IE) is considered a unimicrobial, community-acquired disease of older Caucasian men. PATIENTS AND METHODS: We evaluated the relationship between enterococcal bacteremia and IE by comparing clinical and demographic characteristics of all cases of enterococcal IE within an 8-year period (n = 41) with controls randomly chosen from patients with enterococcal bacteremia without IE. RESULTS: By univariate and multivariable analyses, the presence of a prosthetic valve (PV) and infection with Enterococcus faecalis were significantly associated with IE, while age, gender, race, polymicrobial infection and community-acquired infection were not. Almost an equal number of women and men had enterococcal IE. Cases of enterococcal IE were commonly nosocomial (39%) and polymicrobial (17%). CONCLUSIONS: Enterococcal endocarditis can no longer be considered exclusively a unimicrobial, community-acquired disease of Caucasian men. Instead, our data suggest that the presence of a PV and infection by E. faecalis are associated with an increased risk for IE.

Duke Scholars

Published In

Infection

DOI

ISSN

0300-8126

Publication Date

April 2004

Volume

32

Issue

2

Start / End Page

72 / 77

Location

Germany

Related Subject Headings

  • Survival Analysis
  • Sex Distribution
  • Severity of Illness Index
  • Risk Factors
  • Reference Values
  • Probability
  • Multivariate Analysis
  • Middle Aged
  • Microbiology
  • Microbial Sensitivity Tests
 

Citation

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Anderson, D. J., Murdoch, D. R., Sexton, D. J., Reller, L. B., Stout, J. E., Cabell, C. H., & Corey, G. R. (2004). Risk factors for infective endocarditis in patients with enterococcal bacteremia: a case-control study. Infection, 32(2), 72–77. https://doi.org/10.1007/s15010-004-2036-1
Anderson, D. J., D. R. Murdoch, D. J. Sexton, L. B. Reller, J. E. Stout, C. H. Cabell, and G. R. Corey. “Risk factors for infective endocarditis in patients with enterococcal bacteremia: a case-control study.Infection 32, no. 2 (April 2004): 72–77. https://doi.org/10.1007/s15010-004-2036-1.
Anderson DJ, Murdoch DR, Sexton DJ, Reller LB, Stout JE, Cabell CH, et al. Risk factors for infective endocarditis in patients with enterococcal bacteremia: a case-control study. Infection. 2004 Apr;32(2):72–7.
Anderson, D. J., et al. “Risk factors for infective endocarditis in patients with enterococcal bacteremia: a case-control study.Infection, vol. 32, no. 2, Apr. 2004, pp. 72–77. Pubmed, doi:10.1007/s15010-004-2036-1.
Anderson DJ, Murdoch DR, Sexton DJ, Reller LB, Stout JE, Cabell CH, Corey GR. Risk factors for infective endocarditis in patients with enterococcal bacteremia: a case-control study. Infection. 2004 Apr;32(2):72–77.
Journal cover image

Published In

Infection

DOI

ISSN

0300-8126

Publication Date

April 2004

Volume

32

Issue

2

Start / End Page

72 / 77

Location

Germany

Related Subject Headings

  • Survival Analysis
  • Sex Distribution
  • Severity of Illness Index
  • Risk Factors
  • Reference Values
  • Probability
  • Multivariate Analysis
  • Middle Aged
  • Microbiology
  • Microbial Sensitivity Tests