Skip to main content

Ceftriaxone once daily for four weeks compared with ceftriaxone plus gentamicin once daily for two weeks for treatment of endocarditis due to penicillin-susceptible streptococci. Endocarditis Treatment Consortium Group.

Publication ,  Journal Article
Sexton, DJ; Tenenbaum, MJ; Wilson, WR; Steckelberg, JM; Tice, AD; Gilbert, D; Dismukes, W; Drew, RH; Durack, DT
Published in: Clin Infect Dis
December 1998

This randomized, multicenter, open-label study compared the efficacy and safety of monotherapy with 2 g of intravenous ceftriaxone once daily for 4 weeks with those of combination therapy with 2 g of intravenous ceftriaxone and 3 mg of intravenous gentamicin/kg once daily for 2 weeks as therapy for endocarditis due to penicillin-susceptible streptococci. Sixty-one patients were enrolled in the study. Clinical cure was observed for 51 evaluable patients both at termination of therapy and at the 3-month follow-up: 25 (96.2%) of 26 monotherapy recipients and 24 (96%) of 25 combination therapy recipients. Of the 23 patients in each treatment group who were microbiologically evaluable, 22 (95.7%) in each group were considered cured. No patient had evidence of relapse. Fourteen patients (27.5%) required cardiac surgery after initiation of treatment, including five monotherapy recipients and nine combination therapy recipients. Adverse effects were minimal in both treatment groups. We conclude that 2 g of ceftriaxone once daily for 4 weeks and 2 g of ceftriaxone in combination with 3 mg of gentamicin/kg once daily for 2 weeks are both effective and safe for the treatment of streptococcal endocarditis.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Clin Infect Dis

DOI

ISSN

1058-4838

Publication Date

December 1998

Volume

27

Issue

6

Start / End Page

1470 / 1474

Location

United States

Related Subject Headings

  • Streptococcus
  • Streptococcal Infections
  • Penicillins
  • Middle Aged
  • Microbiology
  • Humans
  • Gentamicins
  • Endocarditis, Bacterial
  • Drug Therapy, Combination
  • Cephalosporins
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sexton, D. J., Tenenbaum, M. J., Wilson, W. R., Steckelberg, J. M., Tice, A. D., Gilbert, D., … Durack, D. T. (1998). Ceftriaxone once daily for four weeks compared with ceftriaxone plus gentamicin once daily for two weeks for treatment of endocarditis due to penicillin-susceptible streptococci. Endocarditis Treatment Consortium Group. Clin Infect Dis, 27(6), 1470–1474. https://doi.org/10.1086/515038
Sexton, D. J., M. J. Tenenbaum, W. R. Wilson, J. M. Steckelberg, A. D. Tice, D. Gilbert, W. Dismukes, R. H. Drew, and D. T. Durack. “Ceftriaxone once daily for four weeks compared with ceftriaxone plus gentamicin once daily for two weeks for treatment of endocarditis due to penicillin-susceptible streptococci. Endocarditis Treatment Consortium Group.Clin Infect Dis 27, no. 6 (December 1998): 1470–74. https://doi.org/10.1086/515038.
Sexton DJ, Tenenbaum MJ, Wilson WR, Steckelberg JM, Tice AD, Gilbert D, Dismukes W, Drew RH, Durack DT. Ceftriaxone once daily for four weeks compared with ceftriaxone plus gentamicin once daily for two weeks for treatment of endocarditis due to penicillin-susceptible streptococci. Endocarditis Treatment Consortium Group. Clin Infect Dis. 1998 Dec;27(6):1470–1474.

Published In

Clin Infect Dis

DOI

ISSN

1058-4838

Publication Date

December 1998

Volume

27

Issue

6

Start / End Page

1470 / 1474

Location

United States

Related Subject Headings

  • Streptococcus
  • Streptococcal Infections
  • Penicillins
  • Middle Aged
  • Microbiology
  • Humans
  • Gentamicins
  • Endocarditis, Bacterial
  • Drug Therapy, Combination
  • Cephalosporins