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Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis.

Publication ,  Journal Article
Devy, L; Huang, L; Naa, L; Yanamandra, N; Pieters, H; Frans, N; Chang, E; Tao, Q; Vanhove, M; Lejeune, A; van Gool, R; Sexton, DJ; Kuang, G ...
Published in: Cancer Res
February 15, 2009

Inhibition of specific matrix metalloproteinases (MMP) is an attractive noncytotoxic approach to cancer therapy. MMP-14, a membrane-bound zinc endopeptidase, has been proposed to play a central role in tumor growth, invasion, and neovascularization. Besides cleaving matrix proteins, MMP-14 activates proMMP-2 leading to an amplification of pericellular proteolytic activity. To examine the contribution of MMP-14 to tumor growth and angiogenesis, we used DX-2400, a highly selective fully human MMP-14 inhibitory antibody discovered using phage display technology. DX-2400 blocked proMMP-2 processing on tumor and endothelial cells, inhibited angiogenesis, and slowed tumor progression and formation of metastatic lesions. The combination of potency, selectivity, and robust in vivo activity shows the potential of a selective MMP-14 inhibitor for the treatment of solid tumors.

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Published In

Cancer Res

DOI

EISSN

1538-7445

Publication Date

February 15, 2009

Volume

69

Issue

4

Start / End Page

1517 / 1526

Location

United States

Related Subject Headings

  • Umbilical Veins
  • Transplantation, Heterologous
  • Transfection
  • Oncology & Carcinogenesis
  • Neovascularization, Pathologic
  • Neoplasm Invasiveness
  • Mice
  • Matrix Metalloproteinase Inhibitors
  • Immunohistochemistry
  • Humans
 

Citation

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Devy, L., Huang, L., Naa, L., Yanamandra, N., Pieters, H., Frans, N., … Dransfield, D. T. (2009). Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis. Cancer Res, 69(4), 1517–1526. https://doi.org/10.1158/0008-5472.CAN-08-3255
Devy, Laetitia, Lili Huang, Laurent Naa, Niranjan Yanamandra, Henk Pieters, Nicolas Frans, Edward Chang, et al. “Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis.Cancer Res 69, no. 4 (February 15, 2009): 1517–26. https://doi.org/10.1158/0008-5472.CAN-08-3255.
Devy L, Huang L, Naa L, Yanamandra N, Pieters H, Frans N, et al. Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis. Cancer Res. 2009 Feb 15;69(4):1517–26.
Devy, Laetitia, et al. “Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis.Cancer Res, vol. 69, no. 4, Feb. 2009, pp. 1517–26. Pubmed, doi:10.1158/0008-5472.CAN-08-3255.
Devy L, Huang L, Naa L, Yanamandra N, Pieters H, Frans N, Chang E, Tao Q, Vanhove M, Lejeune A, van Gool R, Sexton DJ, Kuang G, Rank D, Hogan S, Pazmany C, Ma YL, Schoonbroodt S, Nixon AE, Ladner RC, Hoet R, Henderikx P, Tenhoor C, Rabbani SA, Valentino ML, Wood CR, Dransfield DT. Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis. Cancer Res. 2009 Feb 15;69(4):1517–1526.

Published In

Cancer Res

DOI

EISSN

1538-7445

Publication Date

February 15, 2009

Volume

69

Issue

4

Start / End Page

1517 / 1526

Location

United States

Related Subject Headings

  • Umbilical Veins
  • Transplantation, Heterologous
  • Transfection
  • Oncology & Carcinogenesis
  • Neovascularization, Pathologic
  • Neoplasm Invasiveness
  • Mice
  • Matrix Metalloproteinase Inhibitors
  • Immunohistochemistry
  • Humans