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Mathematics intervention for prevention of neurocognitive deficits in childhood leukemia.

Publication ,  Journal Article
Moore, IM; Hockenberry, MJ; Anhalt, C; McCarthy, K; Krull, KR
Published in: Pediatric blood & cancer
August 2012

Despite evidence that CNS treatment is associated with cognitive and academic impairment, interventions to prevent or mitigate these problems are limited. The purpose was to determine if early intervention can prevent declines in mathematics abilities.Fifty-seven children with ALL were enrolled and randomized to a Mathematics Intervention or Standard Care. Subjects completed neurocognitive assessments prior to the intervention, post-intervention, and 1 year later. Parents received written results and recommendations for use with their school. The Mathematics Intervention was based on Multiple Representation Theory and delivered individually over 1 year.Thirty-two of 57 subjects completed the study and were included in data analyses. These 32 subjects completed all neurocognitive assessments and, for those in the Intervention Group, 40-50 hours of the Mathematics Intervention. There were no group differences on relevant demographic variables; risk stratification; number of intrathecal methotrexate injections; or high dose systemic methotrexate. Significant improvements in calculation and applied mathematics from Baseline to Post-Intervention (P = 0.003 and 0.002, respectively) and in visual working memory from Baseline to 1 year Follow-up (P = 0.02) were observed in the Intervention but not the Standard Care Group. Results from repeated measures ANOVA demonstrated significant between group differences for applied mathematics [F(2,29) = 12.47, P < 0.001] and visual working memory [F(2,29) = 5.53, P = 0.009].The Mathematics Intervention improved mathematics abilities and visual working memory compared to standard care. Future studies are needed to translate the Mathematics Intervention into a "virtual" delivery method more readily available to parents and children.

Duke Scholars

Published In

Pediatric blood & cancer

DOI

EISSN

1545-5017

ISSN

1545-5009

Publication Date

August 2012

Volume

59

Issue

2

Start / End Page

278 / 284

Related Subject Headings

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Oncology & Carcinogenesis
  • Neuropsychological Tests
  • Memory Disorders
  • Mathematics
  • Mathematical Concepts
  • Male
  • Humans
  • Female
  • Early Intervention, Educational
 

Citation

APA
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ICMJE
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Moore, I. M., Hockenberry, M. J., Anhalt, C., McCarthy, K., & Krull, K. R. (2012). Mathematics intervention for prevention of neurocognitive deficits in childhood leukemia. Pediatric Blood & Cancer, 59(2), 278–284. https://doi.org/10.1002/pbc.23354
Moore, Ida M., Marilyn J. Hockenberry, Cynthia Anhalt, Kathy McCarthy, and Kevin R. Krull. “Mathematics intervention for prevention of neurocognitive deficits in childhood leukemia.Pediatric Blood & Cancer 59, no. 2 (August 2012): 278–84. https://doi.org/10.1002/pbc.23354.
Moore IM, Hockenberry MJ, Anhalt C, McCarthy K, Krull KR. Mathematics intervention for prevention of neurocognitive deficits in childhood leukemia. Pediatric blood & cancer. 2012 Aug;59(2):278–84.
Moore, Ida M., et al. “Mathematics intervention for prevention of neurocognitive deficits in childhood leukemia.Pediatric Blood & Cancer, vol. 59, no. 2, Aug. 2012, pp. 278–84. Epmc, doi:10.1002/pbc.23354.
Moore IM, Hockenberry MJ, Anhalt C, McCarthy K, Krull KR. Mathematics intervention for prevention of neurocognitive deficits in childhood leukemia. Pediatric blood & cancer. 2012 Aug;59(2):278–284.
Journal cover image

Published In

Pediatric blood & cancer

DOI

EISSN

1545-5017

ISSN

1545-5009

Publication Date

August 2012

Volume

59

Issue

2

Start / End Page

278 / 284

Related Subject Headings

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Oncology & Carcinogenesis
  • Neuropsychological Tests
  • Memory Disorders
  • Mathematics
  • Mathematical Concepts
  • Male
  • Humans
  • Female
  • Early Intervention, Educational