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Psychosocial protocol for childhood cancer. A conceptual model.

Publication ,  Journal Article
Lauria, MM; Hockenberry Eaton, M; Pawletko, TM; Mauer, AM
Published in: Cancer
September 1996

OBJECTIVE: Despite improved event-free survival of older children with acute lymphocytic leukemia (ALL), infants 50,000/microl), and a higher likelihood of CD-10 (CALLA) negative lymphoblasts (55%). A translocation involving chromosome 11 at band q23 was detected in 27 of 64 cytogenetically informative cases. Treatment was based upon two institutional pilot studies utilizing chemotherapy doses based upon body weight. Important components included remission induction with cyclophosphamide (Ctx), vincristine (Vcr), cytosine arabinoside (Ara-C), and prednisone (Pred) (COAP); consolidation therapy with teniposide (VM-26) and Ara-C; and continuation therapy with alternating pulses of COAP with VM-26/Ara-C separated by a methotrexate (Mtx) and 6-mercaptopurine (6-MP) backbone plus CNS therapy consisting of standard triple intrathecal therapy (TIT) (Mtx/hydrocortisone/Ara-C), which avoided the use of radiotherapy in this population. RESULTS: Seventy-six infants achieved a complete remission (93%). Fifty patients have relapsed: 35 isolated marrow relapses, five isolated CNS relapses, eight combined marrow and CNS relapses, and two other relapses. Actuarial event-free survival was 28% (SE = 5%) at 4 years. Infants >274 days (9 months) at diagnosis had a better outcome than those

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

September 1996

Volume

78

Issue

6

Start / End Page

1345 / 1356

Related Subject Headings

  • Oncology & Carcinogenesis
  • 1117 Public Health and Health Services
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
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Lauria, M. M., Hockenberry Eaton, M., Pawletko, T. M., & Mauer, A. M. (1996). Psychosocial protocol for childhood cancer. A conceptual model. Cancer, 78(6), 1345–1356. https://doi.org/10.1002/(SICI)1097-0142(19960915)78:63.0.C
Lauria, M. M., M. Hockenberry Eaton, T. M. Pawletko, and A. M. Mauer. “Psychosocial protocol for childhood cancer. A conceptual model.Cancer 78, no. 6 (September 1996): 1345–56. https://doi.org/10.1002/(SICI)1097-0142(19960915)78:63.0.C.
Lauria MM, Hockenberry Eaton M, Pawletko TM, Mauer AM. Psychosocial protocol for childhood cancer. A conceptual model. Cancer. 1996 Sep;78(6):1345–56.
Lauria, M. M., et al. “Psychosocial protocol for childhood cancer. A conceptual model.Cancer, vol. 78, no. 6, Sept. 1996, pp. 1345–56. Manual, doi:10.1002/(SICI)1097-0142(19960915)78:63.0.C.
Lauria MM, Hockenberry Eaton M, Pawletko TM, Mauer AM. Psychosocial protocol for childhood cancer. A conceptual model. Cancer. 1996 Sep;78(6):1345–1356.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

September 1996

Volume

78

Issue

6

Start / End Page

1345 / 1356

Related Subject Headings

  • Oncology & Carcinogenesis
  • 1117 Public Health and Health Services
  • 1112 Oncology and Carcinogenesis