Skip to main content

Neurocognitive testing and functioning in adults sickle cell disease.

Publication ,  Journal Article
Feliu, MH; Crawford, RD; Edwards, L; Wellington, C; Wood, M; Whitfield, KE; Edwards, CL
Published in: Hemoglobin
2011

The impact of cerebrovascular events (CVE) on cognitive functioning in adults with sickle cell disease is not well understood. Sequelae of CVEs can adversely impact their quality of life. We reviewed neurocognitive presentation and testing in adults with sickle cell disease. We evaluated the frequency of complaints of memory disturbance using survey methodology in a sample of 109 adult patients with sickle cell disease (48 males, 61 females). A subsample of 24 patients also received a memory questionnaire where specific cognitive functions were assessed. Overall, we found that males and females did not differ in the frequency of experienced memory disturbance during painful crises. However, the frequency of men reporting that their ability to remember where they place common objects such as keys (p = 0.017) and remembering the item they intended to buy in a grocery store or pharmacy (p = 0.048) was worse now compared to when they were in high school and was greater when compared to women. The frequency of men who reported their memory was worse now than when they were in high school (p = 0.051) was also greater than in women. We concluded that memory dysfunction predicts global monthly presentation of pain. We suggest incorporating cost-effective neurocognitive screening measures as a standard of practice in sickle cell disease.

Duke Scholars

Published In

Hemoglobin

DOI

EISSN

1532-432X

Publication Date

2011

Volume

35

Issue

5-6

Start / End Page

476 / 484

Location

England

Related Subject Headings

  • Young Adult
  • Surveys and Questionnaires
  • Middle Aged
  • Male
  • Immunology
  • Humans
  • Female
  • Cognition Disorders
  • Anemia, Sickle Cell
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Feliu, M. H., Crawford, R. D., Edwards, L., Wellington, C., Wood, M., Whitfield, K. E., & Edwards, C. L. (2011). Neurocognitive testing and functioning in adults sickle cell disease. Hemoglobin, 35(5–6), 476–484. https://doi.org/10.3109/03630269.2011.626098
Feliu, Miriam H., Regina D. Crawford, Lekisha Edwards, Chante Wellington, Mary Wood, Keith E. Whitfield, and Christopher L. Edwards. “Neurocognitive testing and functioning in adults sickle cell disease.Hemoglobin 35, no. 5–6 (2011): 476–84. https://doi.org/10.3109/03630269.2011.626098.
Feliu MH, Crawford RD, Edwards L, Wellington C, Wood M, Whitfield KE, et al. Neurocognitive testing and functioning in adults sickle cell disease. Hemoglobin. 2011;35(5–6):476–84.
Feliu, Miriam H., et al. “Neurocognitive testing and functioning in adults sickle cell disease.Hemoglobin, vol. 35, no. 5–6, 2011, pp. 476–84. Pubmed, doi:10.3109/03630269.2011.626098.
Feliu MH, Crawford RD, Edwards L, Wellington C, Wood M, Whitfield KE, Edwards CL. Neurocognitive testing and functioning in adults sickle cell disease. Hemoglobin. 2011;35(5–6):476–484.

Published In

Hemoglobin

DOI

EISSN

1532-432X

Publication Date

2011

Volume

35

Issue

5-6

Start / End Page

476 / 484

Location

England

Related Subject Headings

  • Young Adult
  • Surveys and Questionnaires
  • Middle Aged
  • Male
  • Immunology
  • Humans
  • Female
  • Cognition Disorders
  • Anemia, Sickle Cell
  • Adult