The Valley of Death in anticancer drug development: a reassessment.
Publication
, Journal Article
Adams, DJ
Published in: Trends Pharmacol Sci
April 2012
The past decade has seen an explosion in our understanding of cancer biology and with it many new potential disease targets. Nonetheless, our ability to translate these advances into therapies is poor, with a failure rate approaching 90%. Much discussion has been devoted to this so-called 'Valley of Death' in anticancer drug development, but the problem persists. Could we have overlooked some straightforward explanations to this highly complex problem? Important aspects of tumor physiology, drug pharmacokinetics, preclinical models, drug delivery, and clinical translation are not often emphasized, but could be crucial. This perspective summarizes current views on the problem and suggests feasible alternatives.
Duke Scholars
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Published In
Trends Pharmacol Sci
DOI
EISSN
1873-3735
Publication Date
April 2012
Volume
33
Issue
4
Start / End Page
173 / 180
Location
England
Related Subject Headings
- Pharmacology & Pharmacy
- Neoplasms
- Humans
- Drug Discovery
- Antineoplastic Agents
- Animals
- 3214 Pharmacology and pharmaceutical sciences
- 11 Medical and Health Sciences
- 06 Biological Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Adams, D. J. (2012). The Valley of Death in anticancer drug development: a reassessment. Trends Pharmacol Sci, 33(4), 173–180. https://doi.org/10.1016/j.tips.2012.02.001
Adams, David J. “The Valley of Death in anticancer drug development: a reassessment.” Trends Pharmacol Sci 33, no. 4 (April 2012): 173–80. https://doi.org/10.1016/j.tips.2012.02.001.
Adams DJ. The Valley of Death in anticancer drug development: a reassessment. Trends Pharmacol Sci. 2012 Apr;33(4):173–80.
Adams, David J. “The Valley of Death in anticancer drug development: a reassessment.” Trends Pharmacol Sci, vol. 33, no. 4, Apr. 2012, pp. 173–80. Pubmed, doi:10.1016/j.tips.2012.02.001.
Adams DJ. The Valley of Death in anticancer drug development: a reassessment. Trends Pharmacol Sci. 2012 Apr;33(4):173–180.
Published In
Trends Pharmacol Sci
DOI
EISSN
1873-3735
Publication Date
April 2012
Volume
33
Issue
4
Start / End Page
173 / 180
Location
England
Related Subject Headings
- Pharmacology & Pharmacy
- Neoplasms
- Humans
- Drug Discovery
- Antineoplastic Agents
- Animals
- 3214 Pharmacology and pharmaceutical sciences
- 11 Medical and Health Sciences
- 06 Biological Sciences