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The Valley of Death in anticancer drug development: a reassessment.

Publication ,  Journal Article
Adams, DJ
Published in: Trends Pharmacol Sci
April 2012

The past decade has seen an explosion in our understanding of cancer biology and with it many new potential disease targets. Nonetheless, our ability to translate these advances into therapies is poor, with a failure rate approaching 90%. Much discussion has been devoted to this so-called 'Valley of Death' in anticancer drug development, but the problem persists. Could we have overlooked some straightforward explanations to this highly complex problem? Important aspects of tumor physiology, drug pharmacokinetics, preclinical models, drug delivery, and clinical translation are not often emphasized, but could be crucial. This perspective summarizes current views on the problem and suggests feasible alternatives.

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Published In

Trends Pharmacol Sci

DOI

EISSN

1873-3735

Publication Date

April 2012

Volume

33

Issue

4

Start / End Page

173 / 180

Location

England

Related Subject Headings

  • Pharmacology & Pharmacy
  • Neoplasms
  • Humans
  • Drug Discovery
  • Antineoplastic Agents
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

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Adams, D. J. (2012). The Valley of Death in anticancer drug development: a reassessment. Trends Pharmacol Sci, 33(4), 173–180. https://doi.org/10.1016/j.tips.2012.02.001
Adams, David J. “The Valley of Death in anticancer drug development: a reassessment.Trends Pharmacol Sci 33, no. 4 (April 2012): 173–80. https://doi.org/10.1016/j.tips.2012.02.001.
Adams DJ. The Valley of Death in anticancer drug development: a reassessment. Trends Pharmacol Sci. 2012 Apr;33(4):173–80.
Adams, David J. “The Valley of Death in anticancer drug development: a reassessment.Trends Pharmacol Sci, vol. 33, no. 4, Apr. 2012, pp. 173–80. Pubmed, doi:10.1016/j.tips.2012.02.001.
Adams DJ. The Valley of Death in anticancer drug development: a reassessment. Trends Pharmacol Sci. 2012 Apr;33(4):173–180.
Journal cover image

Published In

Trends Pharmacol Sci

DOI

EISSN

1873-3735

Publication Date

April 2012

Volume

33

Issue

4

Start / End Page

173 / 180

Location

England

Related Subject Headings

  • Pharmacology & Pharmacy
  • Neoplasms
  • Humans
  • Drug Discovery
  • Antineoplastic Agents
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences