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Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse.

Publication ,  Journal Article
Wu, JM; Visco, AG; Grass, EA; Craig, DM; Fulton, RG; Haynes, C; Amundsen, CL; Shah, SH
Published in: Am J Obstet Gynecol
May 2012

OBJECTIVE: We sought to comprehensively evaluate the association of laminin gamma-1 (LAMC1) and advance pelvic organ prolapse. STUDY DESIGN: We conducted a candidate gene association of patients (n = 239) with stages III-IV prolapse and controls (n = 197) with stages 0-I prolapse. We used a linkage disequilibrium (LD)-tagged approach to identify single-nucleotide polymorphisms (SNPs) in LAMC1 and focused on non-Hispanic white women to minimize population stratification. Additive and dominant multivariable logistic regression models were used to test for association between individual SNPs and advanced prolapse. RESULTS: Fourteen SNPs representing 99% coverage of LAMC1 were genotyped. There was no association between SNP rs10911193 and advanced prolapse (P = .34). However, there was a trend toward significance for SNPs rs1413390 (P = .11), rs20563 (P = .11), and rs20558 (P = .12). CONCLUSION: Although we found that the previously reported LAMC1 SNP rs10911193 was not associated with nonfamilial prolapse, our results support further investigation of this candidate gene in the pathophysiology of prolapse.

Duke Scholars

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

May 2012

Volume

206

Issue

5

Start / End Page

447.e1 / 447.e6

Location

United States

Related Subject Headings

  • White People
  • Severity of Illness Index
  • Polymorphism, Single Nucleotide
  • Pelvic Organ Prolapse
  • Obstetrics & Reproductive Medicine
  • Multivariate Analysis
  • Middle Aged
  • Logistic Models
  • Linkage Disequilibrium
  • Laminin
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wu, J. M., Visco, A. G., Grass, E. A., Craig, D. M., Fulton, R. G., Haynes, C., … Shah, S. H. (2012). Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse. Am J Obstet Gynecol, 206(5), 447.e1-447.e6. https://doi.org/10.1016/j.ajog.2012.01.033
Wu, Jennifer M., Anthony G. Visco, Elizabeth A. Grass, Damian M. Craig, Rebekah G. Fulton, Carol Haynes, Cindy L. Amundsen, and Svati H. Shah. “Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse.Am J Obstet Gynecol 206, no. 5 (May 2012): 447.e1-447.e6. https://doi.org/10.1016/j.ajog.2012.01.033.
Wu JM, Visco AG, Grass EA, Craig DM, Fulton RG, Haynes C, et al. Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse. Am J Obstet Gynecol. 2012 May;206(5):447.e1-447.e6.
Wu, Jennifer M., et al. “Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse.Am J Obstet Gynecol, vol. 206, no. 5, May 2012, pp. 447.e1-447.e6. Pubmed, doi:10.1016/j.ajog.2012.01.033.
Wu JM, Visco AG, Grass EA, Craig DM, Fulton RG, Haynes C, Amundsen CL, Shah SH. Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse. Am J Obstet Gynecol. 2012 May;206(5):447.e1-447.e6.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

May 2012

Volume

206

Issue

5

Start / End Page

447.e1 / 447.e6

Location

United States

Related Subject Headings

  • White People
  • Severity of Illness Index
  • Polymorphism, Single Nucleotide
  • Pelvic Organ Prolapse
  • Obstetrics & Reproductive Medicine
  • Multivariate Analysis
  • Middle Aged
  • Logistic Models
  • Linkage Disequilibrium
  • Laminin