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Effects of aging on the neural correlates of successful item and source memory encoding.

Publication ,  Journal Article
Dennis, NA; Hayes, SM; Prince, SE; Madden, DJ; Huettel, SA; Cabeza, R
Published in: J Exp Psychol Learn Mem Cogn
July 2008

To investigate the neural basis of age-related source memory (SM) deficits, young and older adults were scanned with fMRI while encoding faces, scenes, and face-scene pairs. Successful encoding activity was identified by comparing encoding activity for subsequently remembered versus forgotten items or pairs. Age deficits in successful encoding activity in hippocampal and prefrontal regions were more pronounced for SM (pairs) as compared with item memory (faces and scenes). Age-related reductions were also found in regions specialized in processing faces (fusiform face area) and scenes (parahippocampal place area), but these reductions were similar for item and SM. Functional connectivity between the hippocampus and the rest of the brain was also affected by aging; whereas connections with posterior cortices were weaker in older adults, connections with anterior cortices, including prefrontal regions, were stronger in older adults. Taken together, the results provide a link between SM deficits in older adults and reduced recruitment of hippocampal and prefrontal regions during encoding. The functional connectivity findings are consistent with a posterior-anterior shift with aging previously reported in several cognitive domains and linked to functional compensation.

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Published In

J Exp Psychol Learn Mem Cogn

DOI

ISSN

0278-7393

Publication Date

July 2008

Volume

34

Issue

4

Start / End Page

791 / 808

Location

United States

Related Subject Headings

  • Prefrontal Cortex
  • Parahippocampal Gyrus
  • Neuropsychological Tests
  • Memory
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Hippocampus
  • Female
  • Face
 

Citation

APA
Chicago
ICMJE
MLA
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Dennis, N. A., Hayes, S. M., Prince, S. E., Madden, D. J., Huettel, S. A., & Cabeza, R. (2008). Effects of aging on the neural correlates of successful item and source memory encoding. J Exp Psychol Learn Mem Cogn, 34(4), 791–808. https://doi.org/10.1037/0278-7393.34.4.791
Dennis, Nancy A., Scott M. Hayes, Steven E. Prince, David J. Madden, Scott A. Huettel, and Roberto Cabeza. “Effects of aging on the neural correlates of successful item and source memory encoding.J Exp Psychol Learn Mem Cogn 34, no. 4 (July 2008): 791–808. https://doi.org/10.1037/0278-7393.34.4.791.
Dennis NA, Hayes SM, Prince SE, Madden DJ, Huettel SA, Cabeza R. Effects of aging on the neural correlates of successful item and source memory encoding. J Exp Psychol Learn Mem Cogn. 2008 Jul;34(4):791–808.
Dennis, Nancy A., et al. “Effects of aging on the neural correlates of successful item and source memory encoding.J Exp Psychol Learn Mem Cogn, vol. 34, no. 4, July 2008, pp. 791–808. Pubmed, doi:10.1037/0278-7393.34.4.791.
Dennis NA, Hayes SM, Prince SE, Madden DJ, Huettel SA, Cabeza R. Effects of aging on the neural correlates of successful item and source memory encoding. J Exp Psychol Learn Mem Cogn. 2008 Jul;34(4):791–808.

Published In

J Exp Psychol Learn Mem Cogn

DOI

ISSN

0278-7393

Publication Date

July 2008

Volume

34

Issue

4

Start / End Page

791 / 808

Location

United States

Related Subject Headings

  • Prefrontal Cortex
  • Parahippocampal Gyrus
  • Neuropsychological Tests
  • Memory
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Hippocampus
  • Female
  • Face