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Histamine2 receptor antagonist use and decline in cognitive function among community dwelling elderly.

Publication ,  Journal Article
Hanlon, JT; Landerman, LR; Artz, MB; Gray, SL; Fillenbaum, GG; Schmader, KE
Published in: Pharmacoepidemiol Drug Saf
November 2004

PURPOSE: Previous studies have reported mixed results regarding the use of histamine(2) receptor antagonist use and cognitive function. This study evaluated the relationship between the use of histamine(2) receptor antagonists and cognitive decline among community dwelling elderly. METHODS: This cohort study included 2082 subjects from the Duke Established Populations for Epidemiologic Studies of the Elderly who were not cognitively impaired at baseline (1989/90). Histamine(2) receptor antagonist use was determined during in-home interviews. Cognitive function was assessed at 3 and 7 years after baseline by two measures: (1) incident cognitive impairment defined by the short portable mental status questionnaire (SPMSQ); and (2) cognitive decline (increase in two or more SPMSQ errors). Analyzes used multivariable discrete-time hazard models with weighted data adjusted for sampling design and controlled for demographic, health behavior characteristics and health status. RESULTS: At baseline, nearly 5% of participants used a histamine(2) receptor antagonist. During follow-up, incident cognitive impairment occurred in 24.0%, whereas 34.5% increased by two or more errors on the SPMSQ. In multivariable models, current histamine(2) receptor antagonist users compared to never users had a higher risk for cognitive impairment (Adj. RR 1.51; 95%CI 0.93-2.47) and for decline in performance (increase of two or more errors) on the SPMSQ (Adj. RR 1.24; 95%CI 0.74-2.08). A nonsignificant increased risk of cognitive impairment and decline with either higher dose or short-term use was found whereas a nonsignificant protective effect on cognitive decline with current long-term use was seen. CONCLUSIONS: These results suggest no beneficial effects, and perhaps a detrimental effect, of histamine(2) receptor antagonist use on cognitive function in community dwelling elderly.

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Published In

Pharmacoepidemiol Drug Saf

DOI

ISSN

1053-8569

Publication Date

November 2004

Volume

13

Issue

11

Start / End Page

781 / 787

Location

England

Related Subject Headings

  • Pharmacology & Pharmacy
  • Pharmacoepidemiology
  • Male
  • Longitudinal Studies
  • Income
  • Humans
  • Histamine H2 Antagonists
  • Health Status
  • Geriatric Assessment
  • Female
 

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Hanlon, J. T., Landerman, L. R., Artz, M. B., Gray, S. L., Fillenbaum, G. G., & Schmader, K. E. (2004). Histamine2 receptor antagonist use and decline in cognitive function among community dwelling elderly. Pharmacoepidemiol Drug Saf, 13(11), 781–787. https://doi.org/10.1002/pds.952
Hanlon, Joseph T., Lawrence R. Landerman, Margaret B. Artz, Shelly L. Gray, Gerda G. Fillenbaum, and Kenneth E. Schmader. “Histamine2 receptor antagonist use and decline in cognitive function among community dwelling elderly.Pharmacoepidemiol Drug Saf 13, no. 11 (November 2004): 781–87. https://doi.org/10.1002/pds.952.
Hanlon JT, Landerman LR, Artz MB, Gray SL, Fillenbaum GG, Schmader KE. Histamine2 receptor antagonist use and decline in cognitive function among community dwelling elderly. Pharmacoepidemiol Drug Saf. 2004 Nov;13(11):781–7.
Hanlon, Joseph T., et al. “Histamine2 receptor antagonist use and decline in cognitive function among community dwelling elderly.Pharmacoepidemiol Drug Saf, vol. 13, no. 11, Nov. 2004, pp. 781–87. Pubmed, doi:10.1002/pds.952.
Hanlon JT, Landerman LR, Artz MB, Gray SL, Fillenbaum GG, Schmader KE. Histamine2 receptor antagonist use and decline in cognitive function among community dwelling elderly. Pharmacoepidemiol Drug Saf. 2004 Nov;13(11):781–787.
Journal cover image

Published In

Pharmacoepidemiol Drug Saf

DOI

ISSN

1053-8569

Publication Date

November 2004

Volume

13

Issue

11

Start / End Page

781 / 787

Location

England

Related Subject Headings

  • Pharmacology & Pharmacy
  • Pharmacoepidemiology
  • Male
  • Longitudinal Studies
  • Income
  • Humans
  • Histamine H2 Antagonists
  • Health Status
  • Geriatric Assessment
  • Female