Skip to main content

Cerebral infarcts in patients with autopsy-proven Alzheimer's disease: CERAD, part XVIII. Consortium to Establish a Registry for Alzheimer's Disease.

Publication ,  Journal Article
Heyman, A; Fillenbaum, GG; Welsh-Bohmer, KA; Gearing, M; Mirra, SS; Mohs, RC; Peterson, BL; Pieper, CF
Published in: Neurology
July 1998

OBJECTIVE: To study the relation between cerebral infarction and clinical and neuropsychologic manifestations in patients with autopsy-proven Alzheimer's disease (AD) enrolled in the Consortium to Establish a Registry for Alzheimer's Disease (CERAD). BACKGROUND: Prior studies report that subjects with neuropathologic evidence of AD and concomitant brain infarcts had poorer cognitive function and higher frequency of dementia than those with AD alone. METHODS: Clinical and neuropsychologic manifestations of dementia were studied in 74 subjects with neuropathologic findings of AD alone and 32 with AD and concomitant cerebral infarcts or lacunar lesions. RESULTS: The 32 patients with both AD and vascular lesions were significantly older at time of death (median age, 81 years) than the 74 patients with AD alone (76 years; p = 0.02). At the final follow-up visit, the severity of the dementia was greater in AD patients with vascular lesions (median Clinical Dementia Rating [CDR] = 3) than in those with AD alone (CDR = 2; p = 0.03). Patients with AD and vascular lesions performed significantly worse on verbal fluency, Boston Naming, and Mini-Mental State Examination (MMSE) tests. No differences between the groups were observed, however, in the semiquantitative measures of frequency of neuritic plaques or neurofibrillary tangles. CONCLUSIONS: The clinical-neuropathologic correlations in CERAD patients generally confirm those in prior studies, indicating that the presence of cerebral infarction in patients with AD is associated with greater overall severity of clinical dementia and poorer performance on specific tests of language and cognitive function.

Duke Scholars

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

July 1998

Volume

51

Issue

1

Start / End Page

159 / 162

Location

United States

Related Subject Headings

  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Male
  • Humans
  • Female
  • Comorbidity
  • Cerebral Infarction
  • Alzheimer Disease
  • Aged
  • 3209 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Heyman, A., Fillenbaum, G. G., Welsh-Bohmer, K. A., Gearing, M., Mirra, S. S., Mohs, R. C., … Pieper, C. F. (1998). Cerebral infarcts in patients with autopsy-proven Alzheimer's disease: CERAD, part XVIII. Consortium to Establish a Registry for Alzheimer's Disease. Neurology, 51(1), 159–162. https://doi.org/10.1212/wnl.51.1.159
Heyman, A., G. G. Fillenbaum, K. A. Welsh-Bohmer, M. Gearing, S. S. Mirra, R. C. Mohs, B. L. Peterson, and C. F. Pieper. “Cerebral infarcts in patients with autopsy-proven Alzheimer's disease: CERAD, part XVIII. Consortium to Establish a Registry for Alzheimer's Disease.Neurology 51, no. 1 (July 1998): 159–62. https://doi.org/10.1212/wnl.51.1.159.
Heyman A, Fillenbaum GG, Welsh-Bohmer KA, Gearing M, Mirra SS, Mohs RC, et al. Cerebral infarcts in patients with autopsy-proven Alzheimer's disease: CERAD, part XVIII. Consortium to Establish a Registry for Alzheimer's Disease. Neurology. 1998 Jul;51(1):159–62.
Heyman, A., et al. “Cerebral infarcts in patients with autopsy-proven Alzheimer's disease: CERAD, part XVIII. Consortium to Establish a Registry for Alzheimer's Disease.Neurology, vol. 51, no. 1, July 1998, pp. 159–62. Pubmed, doi:10.1212/wnl.51.1.159.
Heyman A, Fillenbaum GG, Welsh-Bohmer KA, Gearing M, Mirra SS, Mohs RC, Peterson BL, Pieper CF. Cerebral infarcts in patients with autopsy-proven Alzheimer's disease: CERAD, part XVIII. Consortium to Establish a Registry for Alzheimer's Disease. Neurology. 1998 Jul;51(1):159–162.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

July 1998

Volume

51

Issue

1

Start / End Page

159 / 162

Location

United States

Related Subject Headings

  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Male
  • Humans
  • Female
  • Comorbidity
  • Cerebral Infarction
  • Alzheimer Disease
  • Aged
  • 3209 Neurosciences