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Comparison of spouse and nonkin controls: the experience of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD).

Publication ,  Journal Article
Smith, DS; Fillenbaum, GG
Published in: Aging (Milano)
June 1994

Normal spouses may be an excellent source of control subjects in research on noninstitutionalized Alzheimer's disease (AD) cases. To determine to what extent spouses might differ from nonkin controls, we compared information on 145 spouses of AD patients with 158 nonkin community volunteers enrolled by 23 centers of the Consortium to Establish a Registry for Alzheimer's Disease. Chi square and 1-way ANOVA analyses indicate that neither at entry nor over the next two years did the two groups of controls differ significantly on demographic characteristics, health status, or performance on neuropsychological measures. However, hierarchical logistic regression showed that, after controlling for demographic characteristics and physical status, dropout was nearly twice as high among spouse controls. Dropout was related to nonreturn of the AD case. Thus, as controls, spouses are viable as long as the cases to whom they are married remain in the study.

Duke Scholars

Published In

Aging (Milano)

DOI

ISSN

0394-9532

Publication Date

June 1994

Volume

6

Issue

3

Start / End Page

151 / 157

Location

Italy

Related Subject Headings

  • Spouses
  • Socioeconomic Factors
  • Registries
  • Patient Dropouts
  • Neuropsychological Tests
  • Multicenter Studies as Topic
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Logistic Models
 

Citation

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Smith, D. S., & Fillenbaum, G. G. (1994). Comparison of spouse and nonkin controls: the experience of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Aging (Milano), 6(3), 151–157. https://doi.org/10.1007/BF03324230
Smith, D. S., and G. G. Fillenbaum. “Comparison of spouse and nonkin controls: the experience of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD).Aging (Milano) 6, no. 3 (June 1994): 151–57. https://doi.org/10.1007/BF03324230.
Smith, D. S., and G. G. Fillenbaum. “Comparison of spouse and nonkin controls: the experience of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD).Aging (Milano), vol. 6, no. 3, June 1994, pp. 151–57. Pubmed, doi:10.1007/BF03324230.
Journal cover image

Published In

Aging (Milano)

DOI

ISSN

0394-9532

Publication Date

June 1994

Volume

6

Issue

3

Start / End Page

151 / 157

Location

Italy

Related Subject Headings

  • Spouses
  • Socioeconomic Factors
  • Registries
  • Patient Dropouts
  • Neuropsychological Tests
  • Multicenter Studies as Topic
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Logistic Models