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APOE epsilon4 and low cholesterol as risks for depression in a biracial elderly community sample.

Publication ,  Journal Article
Blazer, DG; Burchett, BB; Fillenbaum, GG
Published in: Am J Geriatr Psychiatry
2002

OBJECTIVE: The epsilon4 allele of apolipoprotein (APOE) is known to be associated with a number of adverse health outcomes, yet the association of the allele with depression has not been conclusively determined. The authors explored the hypothesis that the epsilon4 allele is a risk factor for depression among older persons with a low cholesterol level (a known risk factor for depression). METHODS: A biracial community sample of 2,550 older African Americans and Whites in North Carolina was genotyped for APOE, tested for cholesterol, and evaluated for depression at both baseline and 4-year follow-up. RESULTS: No relationship was found between the epsilon4 allele and depression or low cholesterol and depression in either cross-sectional or longitudinal analyses. The interaction of the epsilon4 allele and cholesterol was also not associated with depression in controlled analyses. Female gender, less education, being unmarried, and cognitive impairment were associated with depression in cross-sectional controlled analyses; only cognitive impairment was associated with depression in longitudinal analyses. CONCLUSION: Despite the association of the epsilon4 allele with a number of adverse health outcomes, as well as the association between depression and cholesterol in previous studies, no association was found between epsilon4 and low cholesterol or depression in cross-sectional and longitudinal analyses. The interaction of epsilon4 and cholesterol was not associated with depression.

Duke Scholars

Published In

Am J Geriatr Psychiatry

ISSN

1064-7481

Publication Date

2002

Volume

10

Issue

5

Start / End Page

515 / 520

Location

England

Related Subject Headings

  • White People
  • Risk Factors
  • Psychiatric Status Rating Scales
  • North Carolina
  • Marital Status
  • Male
  • Longitudinal Studies
  • Humans
  • Geriatrics
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Blazer, D. G., Burchett, B. B., & Fillenbaum, G. G. (2002). APOE epsilon4 and low cholesterol as risks for depression in a biracial elderly community sample. Am J Geriatr Psychiatry, 10(5), 515–520.
Blazer, Dan G., Bruce B. Burchett, and Gerda G. Fillenbaum. “APOE epsilon4 and low cholesterol as risks for depression in a biracial elderly community sample.Am J Geriatr Psychiatry 10, no. 5 (2002): 515–20.
Blazer DG, Burchett BB, Fillenbaum GG. APOE epsilon4 and low cholesterol as risks for depression in a biracial elderly community sample. Am J Geriatr Psychiatry. 2002;10(5):515–20.
Blazer, Dan G., et al. “APOE epsilon4 and low cholesterol as risks for depression in a biracial elderly community sample.Am J Geriatr Psychiatry, vol. 10, no. 5, 2002, pp. 515–20.
Blazer DG, Burchett BB, Fillenbaum GG. APOE epsilon4 and low cholesterol as risks for depression in a biracial elderly community sample. Am J Geriatr Psychiatry. 2002;10(5):515–520.
Journal cover image

Published In

Am J Geriatr Psychiatry

ISSN

1064-7481

Publication Date

2002

Volume

10

Issue

5

Start / End Page

515 / 520

Location

England

Related Subject Headings

  • White People
  • Risk Factors
  • Psychiatric Status Rating Scales
  • North Carolina
  • Marital Status
  • Male
  • Longitudinal Studies
  • Humans
  • Geriatrics
  • Female