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Relation of prescription nonsteroidal antiinflammatory drug use to cognitive function among community-dwelling elderly.

Publication ,  Journal Article
Hanlon, JT; Schmader, KE; Landerman, LR; Horner, RD; Fillenbaum, GG; Pieper, CF; Wall, WE; Koronkowski, MJ; Cohen, HJ
Published in: Ann Epidemiol
February 1997

PURPOSE: To evaluate the relationship of nonsteroidal antiinflammatory drug (NSAID) use to level of cognitive function in community-dwelling elderly persons. METHODS: The prospective cohort study included 2765 nonproxy subjects from the Duke University Established Populations for Epidemiologic Studies of the Elderly who were cognitively intact at baseline (1986-1987) and alive at follow-up three year later. Cognitive function was assessed by the Short Portable Mental Status Questionnaire (i.e., intact vs. impaired and change in score) and by the individual domains of the Orientation-Memory-Concentration Test (i.e., number of errors). NSAID use, determined from in-home interviews, was coded for chronicity, dose, frequency of use, and prescription status. RESULTS: After controlling for demographic factors as well as health status and behavior, continuous, regularly-scheduled, prescription use of NSAID was associated with preservation of one aspect of cognitive functioning: concentration (beta coefficient, 0.29; 95% confidence interval [CI] -0.54 to -0.04, indicating fewer errors). However, no consistent dose-response relationship was found. Current and prior NSAID use was unrelated to level of cognitive functioning across all five measures; among current users, those taking moderate or high doses (beta coefficient, 0.41; 95% CI, 0.08 to 0.74) made more errors on the memory test compared with those taking low doses (beta coefficient 0.03; 95% CI, -.85 to 0.91). CONCLUSIONS: These results suggest no substantial or consistent protective effect of prescription NSAID use on cognitive function in community-dwelling elderly. However, recent use at higher doses may be associated with memory deterioration in this population.

Duke Scholars

Published In

Ann Epidemiol

DOI

ISSN

1047-2797

Publication Date

February 1997

Volume

7

Issue

2

Start / End Page

87 / 94

Location

United States

Related Subject Headings

  • Prospective Studies
  • Neuropsychological Tests
  • Mental Status Schedule
  • Memory
  • Male
  • Humans
  • Health Status Indicators
  • Female
  • Epidemiology
  • Epidemiologic Methods
 

Citation

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ICMJE
MLA
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Hanlon, J. T., Schmader, K. E., Landerman, L. R., Horner, R. D., Fillenbaum, G. G., Pieper, C. F., … Cohen, H. J. (1997). Relation of prescription nonsteroidal antiinflammatory drug use to cognitive function among community-dwelling elderly. Ann Epidemiol, 7(2), 87–94. https://doi.org/10.1016/s1047-2797(96)00124-x
Hanlon, J. T., K. E. Schmader, L. R. Landerman, R. D. Horner, G. G. Fillenbaum, C. F. Pieper, W. E. Wall, M. J. Koronkowski, and H. J. Cohen. “Relation of prescription nonsteroidal antiinflammatory drug use to cognitive function among community-dwelling elderly.Ann Epidemiol 7, no. 2 (February 1997): 87–94. https://doi.org/10.1016/s1047-2797(96)00124-x.
Hanlon JT, Schmader KE, Landerman LR, Horner RD, Fillenbaum GG, Pieper CF, et al. Relation of prescription nonsteroidal antiinflammatory drug use to cognitive function among community-dwelling elderly. Ann Epidemiol. 1997 Feb;7(2):87–94.
Hanlon, J. T., et al. “Relation of prescription nonsteroidal antiinflammatory drug use to cognitive function among community-dwelling elderly.Ann Epidemiol, vol. 7, no. 2, Feb. 1997, pp. 87–94. Pubmed, doi:10.1016/s1047-2797(96)00124-x.
Hanlon JT, Schmader KE, Landerman LR, Horner RD, Fillenbaum GG, Pieper CF, Wall WE, Koronkowski MJ, Cohen HJ. Relation of prescription nonsteroidal antiinflammatory drug use to cognitive function among community-dwelling elderly. Ann Epidemiol. 1997 Feb;7(2):87–94.
Journal cover image

Published In

Ann Epidemiol

DOI

ISSN

1047-2797

Publication Date

February 1997

Volume

7

Issue

2

Start / End Page

87 / 94

Location

United States

Related Subject Headings

  • Prospective Studies
  • Neuropsychological Tests
  • Mental Status Schedule
  • Memory
  • Male
  • Humans
  • Health Status Indicators
  • Female
  • Epidemiology
  • Epidemiologic Methods