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Traditional approaches to androgen deprivation therapy.

Publication ,  Journal Article
Moul, JW; Evans, CP; Gomella, LG; Roach, M; Dreicer, R
Published in: Urology
November 2011

For most of the past 25 years, 1 of the favored approaches to treating prostate cancer has been the suppression of circulating testosterone with luteinizing hormone-releasing hormone (LHRH) agonists. LHRH agonists produce a downregulation of LHRH receptors and an uncoupling of the LHRH signal transduction mechanism. This leads to a marked reduction in the secretion of bioactive hormones stimulating testosterone production and eventual induction of a reversible, but transient and incomplete, state known as "selective medical hypophysectomy." The treatment with LHRH agonists has proved effective in many settings; however, the dosage and timing strategies depend critically on the patient's disease risk and progression. More recent investigations have suggested that a newer, quicker acting, pure gonadotropin-releasing hormone antagonist might be a preferable treatment approach. It remains a fundamental truth, however, that hormonal therapy is both overused and more toxic than generally appreciated. Therefore, a complete understanding of the indications and applications of this approach is essential for the practice of evidence-based medicine.

Duke Scholars

Published In

Urology

DOI

EISSN

1527-9995

Publication Date

November 2011

Volume

78

Issue

5 Suppl

Start / End Page

S485 / S493

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Time Factors
  • Testosterone
  • Prostatic Neoplasms
  • Neoplasm Recurrence, Local
  • Male
  • Humans
  • Combined Modality Therapy
  • Antineoplastic Agents, Hormonal
  • Androgen Antagonists
 

Citation

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Moul, J. W., Evans, C. P., Gomella, L. G., Roach, M., & Dreicer, R. (2011). Traditional approaches to androgen deprivation therapy. Urology, 78(5 Suppl), S485–S493. https://doi.org/10.1016/j.urology.2011.05.051
Moul, Judd W., Christopher P. Evans, Leonard G. Gomella, Mack Roach, and Robert Dreicer. “Traditional approaches to androgen deprivation therapy.Urology 78, no. 5 Suppl (November 2011): S485–93. https://doi.org/10.1016/j.urology.2011.05.051.
Moul JW, Evans CP, Gomella LG, Roach M, Dreicer R. Traditional approaches to androgen deprivation therapy. Urology. 2011 Nov;78(5 Suppl):S485–93.
Moul, Judd W., et al. “Traditional approaches to androgen deprivation therapy.Urology, vol. 78, no. 5 Suppl, Nov. 2011, pp. S485–93. Pubmed, doi:10.1016/j.urology.2011.05.051.
Moul JW, Evans CP, Gomella LG, Roach M, Dreicer R. Traditional approaches to androgen deprivation therapy. Urology. 2011 Nov;78(5 Suppl):S485–S493.
Journal cover image

Published In

Urology

DOI

EISSN

1527-9995

Publication Date

November 2011

Volume

78

Issue

5 Suppl

Start / End Page

S485 / S493

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Time Factors
  • Testosterone
  • Prostatic Neoplasms
  • Neoplasm Recurrence, Local
  • Male
  • Humans
  • Combined Modality Therapy
  • Antineoplastic Agents, Hormonal
  • Androgen Antagonists