Skip to main content

Timing and patterns of recurrences and deaths from prostate cancer following adjuvant pelvic radiotherapy for pathologic stage T3/4 adenocarcinoma of the prostate.

Publication ,  Journal Article
Anscher, MS; Clough, R; Robertson, CN; Prosnitz, LR; Dahm, P; Walther, P; Donatucci, CF; Albala, DM; Febbo, P; George, DJ; Sun, L; Moul, JW
Published in: Prostate Cancer Prostatic Dis
2006

To determine the timing and patterns of late recurrence after radical prostatectomy (RP) alone or RP plus adjuvant radiotherapy (RT). Between 1970 and 1983, 159 patients underwent RP for newly diagnosed adenocarcinoma of the prostate and were found to have positive surgical margins, extracapsular extension and/or seminal vesicle invasion. Of these, 46 received adjuvant RT and 113 did not. The RT group generally received 45-50 Gy to the whole pelvis, then a boost to the prostate bed (total dose of 55-65 Gy). In the RP group, 62% received neoadjuvant/adjuvant androgen deprivation vs 17% in the RT group. Patients were analyzed with respect to timing and patterns of failure. Only one patient was lost to follow-up. The median follow-up for surviving patients was nearly 20 years. The median time to failure in the surgery group was 7.5 vs 14.7 years in the RT group (P=0.1). Late recurrences were less common in the surgery group than the RT group (9 and 1% at 10 and 15 years, respectively vs 17 and 9%). In contrast to recurrences, nearly half of deaths from prostate cancer occurred more than 10 years after treatment. Deaths from prostate cancer represented 55% of all deaths in these patients. Recurrences beyond 10 years after RP in this group of patients were relatively uncommon. Despite its long natural history, death from prostate cancer was the most common cause of mortality in this population with locally advanced tumors, reflecting the need for more effective therapy.

Duke Scholars

Published In

Prostate Cancer Prostatic Dis

DOI

ISSN

1365-7852

Publication Date

2006

Volume

9

Issue

3

Start / End Page

254 / 260

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Treatment Failure
  • Time Factors
  • Survival Analysis
  • Retrospective Studies
  • Radiotherapy, Adjuvant
  • Radiation Dosage
  • Prostatic Neoplasms
  • Prostatectomy
  • Pelvis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Anscher, M. S., Clough, R., Robertson, C. N., Prosnitz, L. R., Dahm, P., Walther, P., … Moul, J. W. (2006). Timing and patterns of recurrences and deaths from prostate cancer following adjuvant pelvic radiotherapy for pathologic stage T3/4 adenocarcinoma of the prostate. Prostate Cancer Prostatic Dis, 9(3), 254–260. https://doi.org/10.1038/sj.pcan.4500903
Anscher, M. S., R. Clough, C. N. Robertson, L. R. Prosnitz, P. Dahm, P. Walther, C. F. Donatucci, et al. “Timing and patterns of recurrences and deaths from prostate cancer following adjuvant pelvic radiotherapy for pathologic stage T3/4 adenocarcinoma of the prostate.Prostate Cancer Prostatic Dis 9, no. 3 (2006): 254–60. https://doi.org/10.1038/sj.pcan.4500903.
Anscher MS, Clough R, Robertson CN, Prosnitz LR, Dahm P, Walther P, et al. Timing and patterns of recurrences and deaths from prostate cancer following adjuvant pelvic radiotherapy for pathologic stage T3/4 adenocarcinoma of the prostate. Prostate Cancer Prostatic Dis. 2006;9(3):254–60.
Anscher, M. S., et al. “Timing and patterns of recurrences and deaths from prostate cancer following adjuvant pelvic radiotherapy for pathologic stage T3/4 adenocarcinoma of the prostate.Prostate Cancer Prostatic Dis, vol. 9, no. 3, 2006, pp. 254–60. Pubmed, doi:10.1038/sj.pcan.4500903.
Anscher MS, Clough R, Robertson CN, Prosnitz LR, Dahm P, Walther P, Donatucci CF, Albala DM, Febbo P, George DJ, Sun L, Moul JW. Timing and patterns of recurrences and deaths from prostate cancer following adjuvant pelvic radiotherapy for pathologic stage T3/4 adenocarcinoma of the prostate. Prostate Cancer Prostatic Dis. 2006;9(3):254–260.

Published In

Prostate Cancer Prostatic Dis

DOI

ISSN

1365-7852

Publication Date

2006

Volume

9

Issue

3

Start / End Page

254 / 260

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Treatment Failure
  • Time Factors
  • Survival Analysis
  • Retrospective Studies
  • Radiotherapy, Adjuvant
  • Radiation Dosage
  • Prostatic Neoplasms
  • Prostatectomy
  • Pelvis