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Tumor volume, tumor percentage involvement, or prostate volume: which is predictive of prostate-specific antigen recurrence?

Publication ,  Journal Article
Uhlman, MA; Sun, L; Stackhouse, DA; Caire, AA; Polascik, TJ; Robertson, CN; Madden, J; Vollmer, R; Albala, DM; Moul, JW
Published in: Urology
February 2010

OBJECTIVES: To compare the effects of tumor volume (TV), tumor percentage involvement (TPI), and prostate volume (PV) on prostate-specific antigen (PSA) recurrence (PSAR) after radical prostatectomy (RP). METHODS: A cohort of 3528 patients receiving RP between 1988 and 2008 was retrieved from the Duke Prostate Center. Patients were stratified by TV (< 3, 3-6, > 6 cm(3)), TPI (< 10%, 10%-20%, > 20%), and PV (< 35, 35-45, > 45 cm(3)) and their effects on PSAR evaluated using Kaplan-Meier analysis. Clinicopathologic variables included in univariate analysis were age at surgery, race, year of surgery, PSA, pathologic Gleason score, pathologic tumor stage, margin status, extracapsular extension, and seminal vesicle invasion. The effects of TV, TPI, and PV (as continuous and categorical variables) on PSAR were compared using Cox analysis. RESULTS: TPI, TV, and PV were predictive of PSAR (P <.05) in Kaplan-Meier analysis. In multivariate analysis as continuous variables, TPI and PV were predictive of PSAR (hazard ratio [HR] = 1.16 and HR = 0.65, P <.05). As categorical variables, TPI > 20% and PV 10-35 cm(3) were predictive of PSAR (HR = 1.45 and OR = 1.25, P <.05). TV was not predictive of PSAR in either analysis. Pathologic Gleason score > or = 7, PSA, positive margins, seminal vesicle invasion, and tumor stage T3/T4 were found to be predictors of PSAR (P <.05). CONCLUSIONS: TV, TPI, and PV were predictive of PSAR in univariate analysis, but in multivariate analysis, only TPI and PV were predictive of PSAR. TPI and PV should be considered when evaluating, assessing, and counseling patients regarding PSAR risk.

Duke Scholars

Published In

Urology

DOI

EISSN

1527-9995

Publication Date

February 2010

Volume

75

Issue

2

Start / End Page

460 / 466

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Retrospective Studies
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Prostate
  • Prognosis
  • Predictive Value of Tests
  • Organ Size
  • Neoplasm Recurrence, Local
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
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Uhlman, M. A., Sun, L., Stackhouse, D. A., Caire, A. A., Polascik, T. J., Robertson, C. N., … Moul, J. W. (2010). Tumor volume, tumor percentage involvement, or prostate volume: which is predictive of prostate-specific antigen recurrence? Urology, 75(2), 460–466. https://doi.org/10.1016/j.urology.2009.06.059
Uhlman, Matthew A., Leon Sun, Danielle A. Stackhouse, Arthur A. Caire, Thomas J. Polascik, Cary N. Robertson, John Madden, Robin Vollmer, David M. Albala, and Judd W. Moul. “Tumor volume, tumor percentage involvement, or prostate volume: which is predictive of prostate-specific antigen recurrence?Urology 75, no. 2 (February 2010): 460–66. https://doi.org/10.1016/j.urology.2009.06.059.
Uhlman MA, Sun L, Stackhouse DA, Caire AA, Polascik TJ, Robertson CN, et al. Tumor volume, tumor percentage involvement, or prostate volume: which is predictive of prostate-specific antigen recurrence? Urology. 2010 Feb;75(2):460–6.
Uhlman, Matthew A., et al. “Tumor volume, tumor percentage involvement, or prostate volume: which is predictive of prostate-specific antigen recurrence?Urology, vol. 75, no. 2, Feb. 2010, pp. 460–66. Pubmed, doi:10.1016/j.urology.2009.06.059.
Uhlman MA, Sun L, Stackhouse DA, Caire AA, Polascik TJ, Robertson CN, Madden J, Vollmer R, Albala DM, Moul JW. Tumor volume, tumor percentage involvement, or prostate volume: which is predictive of prostate-specific antigen recurrence? Urology. 2010 Feb;75(2):460–466.
Journal cover image

Published In

Urology

DOI

EISSN

1527-9995

Publication Date

February 2010

Volume

75

Issue

2

Start / End Page

460 / 466

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Retrospective Studies
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Prostate
  • Prognosis
  • Predictive Value of Tests
  • Organ Size
  • Neoplasm Recurrence, Local
  • Middle Aged