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Clinical predictors of renal mass pathological features.

Publication ,  Journal Article
Tsivian, M; Mouraviev, V; Albala, DM; Caso, JR; Robertson, CN; Madden, JF; Polascik, TJ
Published in: BJU Int
March 2011

OBJECTIVE: • To evaluate the influence of radiographic tumour size and other preoperative variables on the pathological characteristics of the lesion to determine the distribution of pathological features and assess preoperative risk factors for potentially aggressive versus probably indolent renal lesions. PATIENTS AND METHODS: • Retrospective review of records for 768 patients who underwent surgery for single, sporadic renal mass between 2000 and 2008 in a tertiary academic institution. • Demographic, radiographic and pathological variables were recorded and analysed with regression analyses for risk factors for potentially aggressive pathological features (malignant pathology, high Fuhrman grade, lymphovascular invasion and extracapsular extension). RESULTS: • Malignancy was pathologically confirmed in 628 (81.8%) specimens. • Radiographic size was significantly associated with malignancy (versus benign pathology; OR = 1.13, P= 0.001), high Fuhrman grade (OR = 1.21, P < 0.0001), vascular invasion (OR = 1.19, P < 0.0001) and extracapsular extension (OR = 1.23, P < 0.0001). • Age, symptomatic presentation, solid appearance and radiographic size were independent predictors of potentially aggressive disease, whereas for male gender (OR = 1.43, P= 0.062) a trend toward statistical significance was noted. CONCLUSIONS: • Age, male gender, radiographic size and appearance, as well as symptomatic presentation, are associated with an increased risk of malignant, potentially aggressive disease. • These factors should be considered when evaluating management options for a solitary enhancing renal mass.

Duke Scholars

Published In

BJU Int

DOI

EISSN

1464-410X

Publication Date

March 2011

Volume

107

Issue

5

Start / End Page

735 / 740

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Tumor Burden
  • Radiography
  • Nephrectomy
  • Middle Aged
  • Male
  • Kidney Neoplasms
  • Kidney
  • Humans
  • Female
 

Citation

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Tsivian, M., Mouraviev, V., Albala, D. M., Caso, J. R., Robertson, C. N., Madden, J. F., & Polascik, T. J. (2011). Clinical predictors of renal mass pathological features. BJU Int, 107(5), 735–740. https://doi.org/10.1111/j.1464-410X.2010.09629.x
Tsivian, Matvey, Vladimir Mouraviev, David M. Albala, Jorge R. Caso, Cary N. Robertson, John F. Madden, and Thomas J. Polascik. “Clinical predictors of renal mass pathological features.BJU Int 107, no. 5 (March 2011): 735–40. https://doi.org/10.1111/j.1464-410X.2010.09629.x.
Tsivian M, Mouraviev V, Albala DM, Caso JR, Robertson CN, Madden JF, et al. Clinical predictors of renal mass pathological features. BJU Int. 2011 Mar;107(5):735–40.
Tsivian, Matvey, et al. “Clinical predictors of renal mass pathological features.BJU Int, vol. 107, no. 5, Mar. 2011, pp. 735–40. Pubmed, doi:10.1111/j.1464-410X.2010.09629.x.
Tsivian M, Mouraviev V, Albala DM, Caso JR, Robertson CN, Madden JF, Polascik TJ. Clinical predictors of renal mass pathological features. BJU Int. 2011 Mar;107(5):735–740.
Journal cover image

Published In

BJU Int

DOI

EISSN

1464-410X

Publication Date

March 2011

Volume

107

Issue

5

Start / End Page

735 / 740

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Tumor Burden
  • Radiography
  • Nephrectomy
  • Middle Aged
  • Male
  • Kidney Neoplasms
  • Kidney
  • Humans
  • Female