Convection enhanced delivery of macromolecules for brain tumors.
Publication
, Journal Article
Mehta, AI; Choi, BD; Ajay, D; Raghavan, R; Brady, M; Friedman, AH; Pastan, I; Bigner, DD; Sampson, JH
Published in: Curr Drug Discov Technol
December 2012
The blood brain barrier (BBB) poses a significant challenge for drug delivery of macromolecules into the brain. Convection-enhanced delivery (CED) circumvents the BBB through direct intracerebral infusion using a hydrostatic pressure gradient to transfer therapeutic compounds. The efficacy of CED is dependent on the distribution of the therapeutic agent to the targeted region. Here we present a review of convection enhanced delivery of macromolecules, emphasizing the role of tracers in enabling effective delivery anddiscuss current challenges in the field.
Duke Scholars
Published In
Curr Drug Discov Technol
DOI
EISSN
1875-6220
Publication Date
December 2012
Volume
9
Issue
4
Start / End Page
305 / 310
Location
United Arab Emirates
Related Subject Headings
- Medicinal & Biomolecular Chemistry
- Magnetic Resonance Imaging
- Humans
- Drug Delivery Systems
- Brain Neoplasms
- Antineoplastic Agents
- 3214 Pharmacology and pharmaceutical sciences
- 1115 Pharmacology and Pharmaceutical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Mehta, A. I., Choi, B. D., Ajay, D., Raghavan, R., Brady, M., Friedman, A. H., … Sampson, J. H. (2012). Convection enhanced delivery of macromolecules for brain tumors. Curr Drug Discov Technol, 9(4), 305–310. https://doi.org/10.2174/157016312803305951
Mehta, Ankit I., Bryan D. Choi, Divya Ajay, Raghu Raghavan, Martin Brady, Allan H. Friedman, Ira Pastan, Darell D. Bigner, and John H. Sampson. “Convection enhanced delivery of macromolecules for brain tumors.” Curr Drug Discov Technol 9, no. 4 (December 2012): 305–10. https://doi.org/10.2174/157016312803305951.
Mehta AI, Choi BD, Ajay D, Raghavan R, Brady M, Friedman AH, et al. Convection enhanced delivery of macromolecules for brain tumors. Curr Drug Discov Technol. 2012 Dec;9(4):305–10.
Mehta, Ankit I., et al. “Convection enhanced delivery of macromolecules for brain tumors.” Curr Drug Discov Technol, vol. 9, no. 4, Dec. 2012, pp. 305–10. Pubmed, doi:10.2174/157016312803305951.
Mehta AI, Choi BD, Ajay D, Raghavan R, Brady M, Friedman AH, Pastan I, Bigner DD, Sampson JH. Convection enhanced delivery of macromolecules for brain tumors. Curr Drug Discov Technol. 2012 Dec;9(4):305–310.
Published In
Curr Drug Discov Technol
DOI
EISSN
1875-6220
Publication Date
December 2012
Volume
9
Issue
4
Start / End Page
305 / 310
Location
United Arab Emirates
Related Subject Headings
- Medicinal & Biomolecular Chemistry
- Magnetic Resonance Imaging
- Humans
- Drug Delivery Systems
- Brain Neoplasms
- Antineoplastic Agents
- 3214 Pharmacology and pharmaceutical sciences
- 1115 Pharmacology and Pharmaceutical Sciences