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Inherited thrombophilia in childhood arterial stroke: data from Lebanon.

Publication ,  Journal Article
Muwakkit, SA; Majdalani, M; Hourani, R; Mahfouz, RA; Otrock, ZK; Bilalian, C; Chan, AK; Abboud, M; Mikati, MA
Published in: Pediatr Neurol
September 2011

Pediatric ischemic stroke still represents a burden, and more than half of the survivors will experience cognitive or motor disabilities. The objective of this study was to investigate the role of thrombophilia in a cohort of children with arterial ischemic stroke. The records of infants and children with clinically and radiologically confirmed stroke were reviewed. Patients with venous or perinatal stroke were not included. Thirty-three patients were diagnosed with arterial ischemic stroke. The male/female ratio was 1.75:1. The median age was 4 years. The most frequent clinical manifestations were hemiparesis (54.5%) and seizures (33.3%). Genetic thrombophilia testing was available on 24 patients. Nine of the 24 patients (37.5%) were heterozygous for factor V Leiden. None of the patients carried the factor II G20210A variant. Ten patients (41.7%) were heterozygous and 3 (12.5%) were homozygous for methylenetetrahydrofolate reductase (MTHFR) C677T variant. Fifteen patients (62.5%) had one or more genetic polymorphism. Factor V Leiden was significantly associated with arterial ischemic stroke (P < 0.001). Stroke recurred in 2 children with multiple risk factors and MTHFR C677T mutation. Factor V Leiden is one of the major genetic risk factors for pediatric arterial ischemic stroke in Lebanon. MTHFR C677T was prevalent among patients with recurrent stroke.

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Published In

Pediatr Neurol

DOI

EISSN

1873-5150

Publication Date

September 2011

Volume

45

Issue

3

Start / End Page

155 / 158

Location

United States

Related Subject Headings

  • Thrombophilia
  • Stroke
  • Seizures
  • Reverse Transcriptase Polymerase Chain Reaction
  • Retrospective Studies
  • Prothrombin
  • Polymorphism, Genetic
  • Paresis
  • Neurology & Neurosurgery
  • Methylenetetrahydrofolate Reductase (NADPH2)
 

Citation

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Muwakkit, S. A., Majdalani, M., Hourani, R., Mahfouz, R. A., Otrock, Z. K., Bilalian, C., … Mikati, M. A. (2011). Inherited thrombophilia in childhood arterial stroke: data from Lebanon. Pediatr Neurol, 45(3), 155–158. https://doi.org/10.1016/j.pediatrneurol.2011.03.002
Muwakkit, Samar A., Marianne Majdalani, Roula Hourani, Rami A. Mahfouz, Zaher K. Otrock, Christina Bilalian, Anthony K. Chan, Miguel Abboud, and Mohamad A. Mikati. “Inherited thrombophilia in childhood arterial stroke: data from Lebanon.Pediatr Neurol 45, no. 3 (September 2011): 155–58. https://doi.org/10.1016/j.pediatrneurol.2011.03.002.
Muwakkit SA, Majdalani M, Hourani R, Mahfouz RA, Otrock ZK, Bilalian C, et al. Inherited thrombophilia in childhood arterial stroke: data from Lebanon. Pediatr Neurol. 2011 Sep;45(3):155–8.
Muwakkit, Samar A., et al. “Inherited thrombophilia in childhood arterial stroke: data from Lebanon.Pediatr Neurol, vol. 45, no. 3, Sept. 2011, pp. 155–58. Pubmed, doi:10.1016/j.pediatrneurol.2011.03.002.
Muwakkit SA, Majdalani M, Hourani R, Mahfouz RA, Otrock ZK, Bilalian C, Chan AK, Abboud M, Mikati MA. Inherited thrombophilia in childhood arterial stroke: data from Lebanon. Pediatr Neurol. 2011 Sep;45(3):155–158.
Journal cover image

Published In

Pediatr Neurol

DOI

EISSN

1873-5150

Publication Date

September 2011

Volume

45

Issue

3

Start / End Page

155 / 158

Location

United States

Related Subject Headings

  • Thrombophilia
  • Stroke
  • Seizures
  • Reverse Transcriptase Polymerase Chain Reaction
  • Retrospective Studies
  • Prothrombin
  • Polymorphism, Genetic
  • Paresis
  • Neurology & Neurosurgery
  • Methylenetetrahydrofolate Reductase (NADPH2)