Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase.
Publication
, Journal Article
Maragos, WF; Jakel, R; Chesnut, D; Pocernich, CB; Butterfield, DA; St Clair, D; Cass, WA
Published in: Brain Res
September 29, 2000
We have investigated methamphetamine (MA) toxicity in transgenic mice that overexpress the human form of mitochondrial manganese superoxide dismutase (MnSOD). Our results reveal a significant reduction in the long-term depletion of striatal dopamine and protein oxidation following repeated administration of MA in transgenic vs. non-transgenic littermates. These findings support the notion that ROS contribute to MA-induced brain damage and suggest that mitochondria may play an important role in this form of neurodegeneration.
Duke Scholars
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
September 29, 2000
Volume
878
Issue
1-2
Start / End Page
218 / 222
Location
Netherlands
Related Subject Headings
- Superoxide Dismutase
- Reference Values
- Oxidation-Reduction
- Neurology & Neurosurgery
- Nerve Tissue Proteins
- Mitochondria
- Mice, Transgenic
- Mice
- Methamphetamine
- Humans
Citation
APA
Chicago
ICMJE
MLA
NLM
Maragos, W. F., Jakel, R., Chesnut, D., Pocernich, C. B., Butterfield, D. A., St Clair, D., & Cass, W. A. (2000). Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase. Brain Res, 878(1–2), 218–222. https://doi.org/10.1016/s0006-8993(00)02707-4
Maragos, W. F., R. Jakel, D. Chesnut, C. B. Pocernich, D. A. Butterfield, D. St Clair, and W. A. Cass. “Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase.” Brain Res 878, no. 1–2 (September 29, 2000): 218–22. https://doi.org/10.1016/s0006-8993(00)02707-4.
Maragos WF, Jakel R, Chesnut D, Pocernich CB, Butterfield DA, St Clair D, et al. Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase. Brain Res. 2000 Sep 29;878(1–2):218–22.
Maragos, W. F., et al. “Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase.” Brain Res, vol. 878, no. 1–2, Sept. 2000, pp. 218–22. Pubmed, doi:10.1016/s0006-8993(00)02707-4.
Maragos WF, Jakel R, Chesnut D, Pocernich CB, Butterfield DA, St Clair D, Cass WA. Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase. Brain Res. 2000 Sep 29;878(1–2):218–222.
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
September 29, 2000
Volume
878
Issue
1-2
Start / End Page
218 / 222
Location
Netherlands
Related Subject Headings
- Superoxide Dismutase
- Reference Values
- Oxidation-Reduction
- Neurology & Neurosurgery
- Nerve Tissue Proteins
- Mitochondria
- Mice, Transgenic
- Mice
- Methamphetamine
- Humans