Skip to main content
Journal cover image

Spectral domain optical coherence tomography imaging of geographic atrophy margins.

Publication ,  Journal Article
Bearelly, S; Chau, FY; Koreishi, A; Stinnett, SS; Izatt, JA; Toth, CA
Published in: Ophthalmology
September 2009

OBJECTIVE: To test in vivo whether spectral domain optical coherence tomography (SD-OCT) provides adequate resolution for reproducible measurement of photoreceptor (PR) layer at the margins of geographic atrophy (GA), and if it delineates the relationship between PR layer and retinal pigment epithelium at the margins of GA. DESIGN: Prospective consecutive case series. PARTICIPANTS: Patients with GA secondary to nonneovascular age-related macular degeneration (AMD) identified during routine follow-up at Duke Eye Center between January 3, 2006, and June 3, 2007, and who consented to participate in this study. METHODS: We used SD-OCT to image eyes. Multiple B-scans from each eye were saved and independently graded by 2 graders and the following locations were marked: (1) site where PR thickness began to decline below its baseline, (2) site where PR layer disappeared, and (3) site of the GA margin. These data were processed to calculate the locations of PR losses relative to GA margins and were categorized as (A) bridging across GA margins, (B) entirely within GA margins, or (C) entirely outside GA margins. MAIN OUTCOME MEASURES: Location of PR loss (bridging across GA margins, entirely within GA margins, or entirely outside GA margins) was calculated. Distances from the GA margin were measured for beginning and ending of PR loss. Interobserver agreement was determined for categories of PR loss as well as locations of PR loss relative to the GA margin. RESULTS: We analyzed 500 unique scans. The PR loss occurred most frequently bridging across the GA margin (65% scans), second most frequently entirely inside the GA margin (29% scans), and least frequently entirely outside the GA margin (6% scans). Loss of PR started an average of 61 microm (standard deviation [SD] +/- 235) outside the GA margin, ended an average of 311+/-273 microm inside the GA margin, and spanned an average of 372+/-179 microm. CONCLUSIONS: Relative to GA margins in non-neovascular AMD with GA, SD-OCT provides adequate resolution for quantifying PR loss. It may also serve as a means of tracking disease progression in future interventional trials. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.

Duke Scholars

Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

September 2009

Volume

116

Issue

9

Start / End Page

1762 / 1769

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Pigment Epithelium
  • Reproducibility of Results
  • Prospective Studies
  • Photoreceptor Cells, Vertebrate
  • Ophthalmology & Optometry
  • Observer Variation
  • Middle Aged
  • Male
  • Macular Degeneration
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bearelly, S., Chau, F. Y., Koreishi, A., Stinnett, S. S., Izatt, J. A., & Toth, C. A. (2009). Spectral domain optical coherence tomography imaging of geographic atrophy margins. Ophthalmology, 116(9), 1762–1769. https://doi.org/10.1016/j.ophtha.2009.04.015
Bearelly, Srilaxmi, Felix Y. Chau, Anjum Koreishi, Sandra S. Stinnett, Joseph A. Izatt, and Cynthia A. Toth. “Spectral domain optical coherence tomography imaging of geographic atrophy margins.Ophthalmology 116, no. 9 (September 2009): 1762–69. https://doi.org/10.1016/j.ophtha.2009.04.015.
Bearelly S, Chau FY, Koreishi A, Stinnett SS, Izatt JA, Toth CA. Spectral domain optical coherence tomography imaging of geographic atrophy margins. Ophthalmology. 2009 Sep;116(9):1762–9.
Bearelly, Srilaxmi, et al. “Spectral domain optical coherence tomography imaging of geographic atrophy margins.Ophthalmology, vol. 116, no. 9, Sept. 2009, pp. 1762–69. Pubmed, doi:10.1016/j.ophtha.2009.04.015.
Bearelly S, Chau FY, Koreishi A, Stinnett SS, Izatt JA, Toth CA. Spectral domain optical coherence tomography imaging of geographic atrophy margins. Ophthalmology. 2009 Sep;116(9):1762–1769.
Journal cover image

Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

September 2009

Volume

116

Issue

9

Start / End Page

1762 / 1769

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Pigment Epithelium
  • Reproducibility of Results
  • Prospective Studies
  • Photoreceptor Cells, Vertebrate
  • Ophthalmology & Optometry
  • Observer Variation
  • Middle Aged
  • Male
  • Macular Degeneration