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Effects of the dietary approaches to stop hypertension diet alone and in combination with exercise and caloric restriction on insulin sensitivity and lipids.

Publication ,  Journal Article
Blumenthal, JA; Babyak, MA; Sherwood, A; Craighead, L; Lin, P-H; Johnson, J; Watkins, LL; Wang, JT; Kuhn, C; Feinglos, M; Hinderliter, A
Published in: Hypertension
May 2010

This study examined the effects of the Dietary Approaches to Stop Hypertension (DASH) diet on insulin sensitivity and lipids. In a randomized control trial, 144 overweight (body mass index: 25 to 40) men (n=47) and women (n=97) with high blood pressure (130 to 159/85 to 99 mm Hg) were randomly assigned to one of the following groups: (1) DASH diet alone; (2) DASH diet with aerobic exercise and caloric restriction; or (3) usual diet controls (UC). Body composition, fitness, insulin sensitivity, and fasting lipids were measured before and after 4 months of treatment. Insulin sensitivity was estimated on the basis of glucose and insulin levels in the fasting state and after an oral glucose load. Participants in the DASH diet with aerobic exercise and caloric restriction condition lost weight (-8.7 kg [95% CI: -2.0 to -9.7 kg]) and exhibited a significant increase in aerobic capacity, whereas the DASH diet alone and UC participants maintained their weight (-0.3 kg [95% CI: -1.2 to 0.5 kg] and +0.9 kg [95% CI: 0.0 to 1.7 kg], respectively) and had no improvement in exercise capacity. DASH diet with aerobic exercise and caloric restriction demonstrated lower glucose levels after the oral glucose load, improved insulin sensitivity, and lower total cholesterol and triglycerides compared with both DASH diet alone and UC, as well as lower fasting glucose and low-density lipoprotein cholesterol compared with UC. DASH diet alone participants generally did not differ from UC in these measures. Combining the DASH diet with exercise and weight loss resulted in significant improvements in insulin sensitivity and lipids. Despite clinically significant reductions in blood pressure, the DASH diet alone, without caloric restriction or exercise, resulted in minimal improvements in insulin sensitivity or lipids.

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Published In

Hypertension

DOI

EISSN

1524-4563

Publication Date

May 2010

Volume

55

Issue

5

Start / End Page

1199 / 1205

Location

United States

Related Subject Headings

  • Overweight
  • Obesity
  • Middle Aged
  • Male
  • Lipids
  • Insulin
  • Hypertension
  • Humans
  • Glucose Tolerance Test
  • Female
 

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Chicago
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MLA
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Blumenthal, J. A., Babyak, M. A., Sherwood, A., Craighead, L., Lin, P.-H., Johnson, J., … Hinderliter, A. (2010). Effects of the dietary approaches to stop hypertension diet alone and in combination with exercise and caloric restriction on insulin sensitivity and lipids. Hypertension, 55(5), 1199–1205. https://doi.org/10.1161/HYPERTENSIONAHA.109.149153
Blumenthal, James A., Michael A. Babyak, Andrew Sherwood, Linda Craighead, Pao-Hwa Lin, Julie Johnson, Lana L. Watkins, et al. “Effects of the dietary approaches to stop hypertension diet alone and in combination with exercise and caloric restriction on insulin sensitivity and lipids.Hypertension 55, no. 5 (May 2010): 1199–1205. https://doi.org/10.1161/HYPERTENSIONAHA.109.149153.
Blumenthal JA, Babyak MA, Sherwood A, Craighead L, Lin P-H, Johnson J, et al. Effects of the dietary approaches to stop hypertension diet alone and in combination with exercise and caloric restriction on insulin sensitivity and lipids. Hypertension. 2010 May;55(5):1199–205.
Blumenthal, James A., et al. “Effects of the dietary approaches to stop hypertension diet alone and in combination with exercise and caloric restriction on insulin sensitivity and lipids.Hypertension, vol. 55, no. 5, May 2010, pp. 1199–205. Pubmed, doi:10.1161/HYPERTENSIONAHA.109.149153.
Blumenthal JA, Babyak MA, Sherwood A, Craighead L, Lin P-H, Johnson J, Watkins LL, Wang JT, Kuhn C, Feinglos M, Hinderliter A. Effects of the dietary approaches to stop hypertension diet alone and in combination with exercise and caloric restriction on insulin sensitivity and lipids. Hypertension. 2010 May;55(5):1199–1205.

Published In

Hypertension

DOI

EISSN

1524-4563

Publication Date

May 2010

Volume

55

Issue

5

Start / End Page

1199 / 1205

Location

United States

Related Subject Headings

  • Overweight
  • Obesity
  • Middle Aged
  • Male
  • Lipids
  • Insulin
  • Hypertension
  • Humans
  • Glucose Tolerance Test
  • Female