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Chemotherapy-related changes in central nervous system phospholipids and neurocognitive function in childhood acute lymphoblastic leukemia.

Publication ,  Journal Article
Krull, KR; Hockenberry, MJ; Miketova, P; Carey, M; Moore, IM
Published in: Leukemia & lymphoma
August 2012

Long-term survivors of childhood leukemia are at risk for neurocognitive impairment, although the neurophysiological basis is not well understood. The purpose of this study was to explore associations between changes in cerebrospinal fluid (CSF) phospholipids and neurocognitive function in children undergoing chemotherapy for acute lymphoblastic leukemia. Seventy-six children were followed prospectively from diagnosis. CSF samples were collected during scheduled lumbar punctures and phospholipids were extracted. Neurocognitive evaluations were conducted annually beginning shortly after diagnosis. Concentrations of sphingomyelin (SM) increased following induction (p = 0.03) and consolidation (p = 0.04), while lysophosphatidylcholine (LPC) increased following induction (p = 0.003). Multivariable analyses demonstrated associations between post-induction SM and motor speed at 1 year (p

Duke Scholars

Published In

Leukemia & lymphoma

DOI

ISSN

1029-2403

Publication Date

August 2012

Related Subject Headings

  • Time Factors
  • Sphingomyelins
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Phospholipids
  • Phosphatidylethanolamines
  • Phosphatidylcholines
  • Outcome Assessment, Health Care
  • Neuropsychological Tests
  • Multivariate Analysis
  • Methotrexate
 

Citation

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MLA
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Krull, K. R., Hockenberry, M. J., Miketova, P., Carey, M., & Moore, I. M. (2012). Chemotherapy-related changes in central nervous system phospholipids and neurocognitive function in childhood acute lymphoblastic leukemia. Leukemia & Lymphoma. https://doi.org/10.3109/10428194.2012.717080
Krull, K. R., M. J. Hockenberry, P. Miketova, M. Carey, and I. M. Moore. “Chemotherapy-related changes in central nervous system phospholipids and neurocognitive function in childhood acute lymphoblastic leukemia.Leukemia & Lymphoma, August 2012. https://doi.org/10.3109/10428194.2012.717080.
Krull, K. R., et al. “Chemotherapy-related changes in central nervous system phospholipids and neurocognitive function in childhood acute lymphoblastic leukemia.Leukemia & Lymphoma, Aug. 2012. Manual, doi:10.3109/10428194.2012.717080.

Published In

Leukemia & lymphoma

DOI

ISSN

1029-2403

Publication Date

August 2012

Related Subject Headings

  • Time Factors
  • Sphingomyelins
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Phospholipids
  • Phosphatidylethanolamines
  • Phosphatidylcholines
  • Outcome Assessment, Health Care
  • Neuropsychological Tests
  • Multivariate Analysis
  • Methotrexate