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Systemic markers of oxidative status and colorectal adenomatous polyps.

Publication ,  Journal Article
Siamakpour-Reihani, S; Scarbrough, PM; Wang, F; Spasojevic, I; Base, K; Sedjo, R; D'Agostino, RB; Il'yasova, D
Published in: Ann Epidemiol
August 2012

PURPOSE: Oxidative damage has been implicated in carcinogenesis. We hypothesized that elevated systemic oxidative status would be associated with later occurrence of colorectal adenomatous polyps, a precursor of colorectal cancer. METHODS: We examined the prospective association between four systemic markers of oxidative status and colorectal adenomatous polyps within a nondiabetic subcohort of the Insulin Resistance Atherosclerosis Study (n = 425). Urine samples were collected from 1992 to 1994 and colorectal adenomas prevalence were assessed in 2002 to 2004. Oxidative status markers were assessed, which included four F(2)-isoprostanes (F(2)-IsoPs) from the classes III and IV: iPF2α-III, 2,3-dinor-iPF2α-III (a metabolite of iPF2α-III), iPF2α-VI, and 8,12-iso-iPF2α-VI. All biomarkers were quantified using liquid chromatography-tandem mass spectrometry. Prospective associations were assessed using multivariate logistic regression analysis. RESULTS: The adjusted odds ratio (OR) (95% confidence interval [CI]) for occurrence of colorectal adenomatous polyps and scaled to 1 SD of F(2)-IsoP distribution were 1.16 (95% CI, 0.88-1.50), 0.88 (95% CI, 0.63-1.17), 1.04 (95% CI, 0.80-1.34), and 1.16 (95% CI, 0.90-1.48) for iPF2α-III, iPF2α-VI, 8,12-iso-iPF2α-VI, and 2,3-dinor-iPF2α-III, respectively. CONCLUSIONS: The lack of association between F(2)-IsoPs and adenomatous polyps does not support the hypothesis that elevated oxidative status is associated with colorectal adenomatous polyp occurrence during a 10-year period of follow-up.

Duke Scholars

Published In

Ann Epidemiol

DOI

EISSN

1873-2585

Publication Date

August 2012

Volume

22

Issue

8

Start / End Page

587 / 591

Location

United States

Related Subject Headings

  • United States
  • Smoking
  • Prevalence
  • Precancerous Conditions
  • Oxidative Stress
  • Oxidation-Reduction
  • Overweight
  • Middle Aged
  • Male
  • Logistic Models
 

Citation

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Siamakpour-Reihani, S., Scarbrough, P. M., Wang, F., Spasojevic, I., Base, K., Sedjo, R., … Il’yasova, D. (2012). Systemic markers of oxidative status and colorectal adenomatous polyps. Ann Epidemiol, 22(8), 587–591. https://doi.org/10.1016/j.annepidem.2012.05.001
Siamakpour-Reihani, Sharareh, Peter M. Scarbrough, Frances Wang, Ivan Spasojevic, Karel Base, Rebecca Sedjo, Ralph B. D’Agostino, and Dora Il’yasova. “Systemic markers of oxidative status and colorectal adenomatous polyps.Ann Epidemiol 22, no. 8 (August 2012): 587–91. https://doi.org/10.1016/j.annepidem.2012.05.001.
Siamakpour-Reihani S, Scarbrough PM, Wang F, Spasojevic I, Base K, Sedjo R, et al. Systemic markers of oxidative status and colorectal adenomatous polyps. Ann Epidemiol. 2012 Aug;22(8):587–91.
Siamakpour-Reihani, Sharareh, et al. “Systemic markers of oxidative status and colorectal adenomatous polyps.Ann Epidemiol, vol. 22, no. 8, Aug. 2012, pp. 587–91. Pubmed, doi:10.1016/j.annepidem.2012.05.001.
Siamakpour-Reihani S, Scarbrough PM, Wang F, Spasojevic I, Base K, Sedjo R, D’Agostino RB, Il’yasova D. Systemic markers of oxidative status and colorectal adenomatous polyps. Ann Epidemiol. 2012 Aug;22(8):587–591.
Journal cover image

Published In

Ann Epidemiol

DOI

EISSN

1873-2585

Publication Date

August 2012

Volume

22

Issue

8

Start / End Page

587 / 591

Location

United States

Related Subject Headings

  • United States
  • Smoking
  • Prevalence
  • Precancerous Conditions
  • Oxidative Stress
  • Oxidation-Reduction
  • Overweight
  • Middle Aged
  • Male
  • Logistic Models