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Hematopoietic cell infusion for the treatment of nuclear disaster victims: new data from the Chernobyl accident.

Publication ,  Journal Article
Klymenko, SV; Belyi, DA; Ross, JR; Owzar, K; Jiang, C; Li, Z; N Minchenko, J; N Kovalenko, A; Bebeshko, VG; J Chao, N
Published in: Int J Radiat Biol
August 2011

PURPOSE: To present previously unavailable data on the use of stem cell administration to aid recovery of victims of the Chernobyl disaster. On 26 April 1986, an accident at Unit 4 of the Chernobyl Nuclear Power Plant took place during the planned test of one of the safety systems. The diagnosis of acute radiation syndrome (ARS) was confirmed in 134 individuals exposed to high levels of radiation. There were nine patients heretofore unreported in the scientific literature who underwent intraosseous injections of allogeneic bone marrow cells in Kyiv. CONCLUSIONS: Transplantation was associated with significantly shortened time to recovery of granulocyte and platelet counts in these patients. While current guidelines would certainly include the use of cytokines, these data provide an indication of the effectiveness of stem cell transplant to treat victims of radiation exposure.

Duke Scholars

Published In

Int J Radiat Biol

DOI

EISSN

1362-3095

Publication Date

August 2011

Volume

87

Issue

8

Start / End Page

846 / 850

Location

England

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Chernobyl Nuclear Accident
  • Adult
  • Acute Radiation Syndrome
 

Citation

APA
Chicago
ICMJE
MLA
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Klymenko, S. V., Belyi, D. A., Ross, J. R., Owzar, K., Jiang, C., Li, Z., … J Chao, N. (2011). Hematopoietic cell infusion for the treatment of nuclear disaster victims: new data from the Chernobyl accident. Int J Radiat Biol, 87(8), 846–850. https://doi.org/10.3109/09553002.2011.560995
Klymenko, Sergiy V., David A. Belyi, Joel R. Ross, Kouros Owzar, Chen Jiang, Zhiguo Li, Janna N Minchenko, Aleksandr N Kovalenko, Volodymyr G. Bebeshko, and Nelson J Chao. “Hematopoietic cell infusion for the treatment of nuclear disaster victims: new data from the Chernobyl accident.Int J Radiat Biol 87, no. 8 (August 2011): 846–50. https://doi.org/10.3109/09553002.2011.560995.
Klymenko SV, Belyi DA, Ross JR, Owzar K, Jiang C, Li Z, et al. Hematopoietic cell infusion for the treatment of nuclear disaster victims: new data from the Chernobyl accident. Int J Radiat Biol. 2011 Aug;87(8):846–50.
Klymenko, Sergiy V., et al. “Hematopoietic cell infusion for the treatment of nuclear disaster victims: new data from the Chernobyl accident.Int J Radiat Biol, vol. 87, no. 8, Aug. 2011, pp. 846–50. Pubmed, doi:10.3109/09553002.2011.560995.
Klymenko SV, Belyi DA, Ross JR, Owzar K, Jiang C, Li Z, N Minchenko J, N Kovalenko A, Bebeshko VG, J Chao N. Hematopoietic cell infusion for the treatment of nuclear disaster victims: new data from the Chernobyl accident. Int J Radiat Biol. 2011 Aug;87(8):846–850.

Published In

Int J Radiat Biol

DOI

EISSN

1362-3095

Publication Date

August 2011

Volume

87

Issue

8

Start / End Page

846 / 850

Location

England

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Chernobyl Nuclear Accident
  • Adult
  • Acute Radiation Syndrome